Be Advised Of Hazardous Driving Conditions

Be Advised Of Hazardous Driving Conditions

first_imgThe City of Soldotna released a statement, driving conditions are very hazardous right now. City sanding trucks are out, and we want to encourage everyone to drive very carefully, or stay home if don’t have to be out on the roads. Plan ahead for icy driving/difficult driving conditions if you are heading to Anchorage from the Kenai Peninsula within the next 24 hours. Travel still not advised by the Department of Transportation on the Seward Highway due to the recent landslide danger. Drivers should expect wet and icy roads, icy patches, ice glaze, ice, black ice, slippery road surface, reduce your speed, ice on bridges/overpasses.center_img Facebook0TwitterEmailPrintFriendly分享The recent rainfall and freezing temperatures have caused very difficult driving conditions in the Kenai Peninsula area.last_img read more

What Are Town Boards Committees Talking About Week of August 26 2018

What Are Town Boards Committees Talking About Week of August 26 2018

first_imgWILMINGTON, MA — According to the Wilmington Town Clerk’s calendar, below are the town and school board, committee and commission meeting scheduled for the week of Sunday, August 26, 2018.Sunday, August 26No MeetingsMonday, August 27The Wilmington Community Development Technical Review Team meets at 9:30am in Town Hall’s Room 9. Read the agenda HERE.Tuesday, August 28The Shawsheen Tech School Committee meets at 7:30pm in the John P. Miller School Committee Room at the Tech. Read the agenda HERE.Wednesday, August 29The Wilmington School Committee meets at 7pm in the High School’s Large Instruction Room. Read the agenda HERE.Thursday, August 30No MeetingsFriday, August 31No MeetingsSaturday, September 1No MeetingsAll meetings are open to the public unless noted.(NOTE: While unlikely, it is possible additional meetings could be added to this week’s calendar on Wednesday, Thursday, or Friday.  It’s best to check the Town Clerk’s calendar mid-week.)Like Wilmington Apple on Facebook. Follow Wilmington Apple on Twitter. Follow Wilmington Apple on Instagram. Subscribe to Wilmington Apple’s daily email newsletter HERE. Got a comment, question, photo, press release, or news tip? Email wilmingtonapple@gmail.com.Share this:TwitterFacebookLike this:Like Loading… RelatedWhat Are Town Boards & Committees Talking About? (Week of August 25, 2019)In “Government”What Are Town Boards & Committees Talking About? (Week of August 18, 2019)In “Government”What Are Town Boards & Committees Talking About? (Week of June 23, 2019)In “Government”last_img read more

Heres all about Maitri Bridge over Indus river Longest suspension bridge made

first_imgMaitri Bridge in Leh-LadakhTwitterMaitri Bridge, the 260-feet long suspension bridge, was built in just 40 days over the Indus river in Jammu and Kashmir’s Leh district. It was opened to the public on Monday, April 1.The bridge is situated at Choglamsar village in Leh and is the longest suspension bridge over the Indus river.The name Maitri symbolises the friendship between the military personnel and locals. The bridge was constructed by Combat Engineers of the Sahas Aur Yogyata Regiment of Indian Army’s Fire and Fury Corps in a record time of 40 days. Almost 500 tonnes of equipment and construction material were taken to the location, reports ANI.  The bridge will help the residents of Choglamsar, Stok and Chuchot, which are said to be the largest villages in the regionTwitterAccording to India Today, the bridge has been constructed to help the residents of Choglamsar, Stok and Chuchot.According to ANI, the bridge was inaugurated by war veterans who were part of 1947-48, 1962, 1971 and 1999 operations in Jammu and Kashmir. They were led by an 89-year-old war veteran, Naik Phunchok Angdus (retd). The opening ceremony was conducted in the presence of Lt Gen YK Joshi, General Officer Commanding, Fire and Fury Corps.  Other army veterans, senior army officials and civil administrators were present during the opening of the bridge.Twitter 89-year-old war veteran, Naik Phunchok Angdus (retd) formally opening Maitri BridgeTwitterlast_img read more

WATCH What You Need To Know About This Seasons Brutal Flu

WATCH What You Need To Know About This Seasons Brutal Flu

first_imgDoctor visits are climbing and pediatric deaths from the illness are up as well. What makes it so severe? Dr. Amber Robins of Georgetown University joins John Yang to discuss the flu vaccine and other tips for prevention. Sharelast_img

Cardinals at No 9 in Collegiate Baseball Newspaper Preseason Poll

first_imgFOLLOWING THE CARDINALS ON SOCIAL MEDIAFans can follow Louisville baseball on Twitter at @UofLBaseball and on Facebook at http://www.facebook.com/ulbaseball. 2019 Collegiate Baseball Preseason Top 40 Print Friendly Version Story Links LOUISVILLE, Ky. – The University of Louisville baseball program will enter 2019 in a familiar place after landing at No. 9 in the Collegiate Baseball newspaper preseason poll released Tuesday.The announcement marks the 12th consecutive year (2008-2019) the Cardinals have earned a preseason national ranking extending their school record streak. Tuesday’s preseason poll extended another historic run for Louisville, which has remained ranked in at least one major national poll every week since the release of the 2012 preseason rankings — the longest such span in school history.Atop the Collegiate Baseball preseason poll is LSU while No. 2 Vanderbilt, No. 3 UCLA, No. 4 Texas Tech and No. 5 Stanford round out the top five. The Cardinals are among eight ACC programs in the top 40 joining No. 8 North Carolina, No. 10 Florida State, No. 15 Clemson, No. 17 Georgia Tech, No. 20 Duke, No. 22 NC State and No. 33 Miami.Last season, Louisville registered a 45-19 record overall after advancing to the championship round of an NCAA Regional for the seventh straight season. The Cardinals were ranked as highly as 23rd by Collegiate Baseball newspaper while also landing at No. 25 in the USA Today Top 25 and 27th in the National Collegiate Baseball Writers Association poll. Louisville registered its seventh straight 40-win season and the 11th in 12 seasons under head coach Dan McDonnell.Led by the return of All-American first baseman Logan Wyatt and All-ACC standouts Nick Bennett (LHP), Bobby Miller (RHP) and Danny Oriente (OF/DH), the Cardinals are scheduled to open the 2019 season against UConn with a three-game series on Feb. 15-17 at Joker Marchant Stadium in Lakeland, Florida, the spring training home of the Detroit Tigers. Louisville’s home-opener at Jim Patterson Stadium is set for Feb. 20 at 3 p.m., ET against Eastern Kentucky.2019 LOUISVILLE BASEBALL SEASON TICKETSAfter one season of ticketed admission for all home games, the Cardinals are giving free admission back to the fans in 2019. Louisville’s 15 ACC games as well as non-conference games against UK and Vanderbilt will be ticketed events at Jim Patterson Stadium. All other non-conference matchups, including games against Ole Miss, Western Kentucky and Xavier, will have free admission.The 2019 reserved chairback ticket packages, which include one ticket to each of the 17 ticketed games, are priced at $110 for adults, $90 for senior adults/youths and $90 for families of four or more. Season tickets for the Left Field Berm are also available at $50 per ticket. Season tickets are on sale now and can be purchased online here, by calling 502-GO-CARDS or by visiting the Louisville Cardinals Ticket Office, located near Gate 2 at Cardinal Stadium (2800 South Floyd Street) on weekdays from 9 a.m., until 5 p.m., ET. Complete details on 2019 UofL baseball tickets can be found at gocards.com/bsbtickets.last_img read more

Browsers on the Move

first_img Opinions expressed by Entrepreneur contributors are their own. Attend this free webinar and learn how you can maximize efficiency while getting the most critical things done right. Free Webinar | Sept 5: Tips and Tools for Making Progress Toward Important Goals Register Now » November 14, 2008 2 min read You may be perfectly happy with whatever web browser came with your smartphone, but you’re not necessarily restricted to using only that browser. Opera Mobile (opera.com) is available for phones running Windows Mobile and S60 operating systems. The program typically costs $24 (though the 9.5 Beta version was released as freeware). Opera Mobile 9.5 ups the ante with improved speeds, pan and zoom functions, and a revamped tabbed browsing experience. Opera Mini is already a popular choice for a browser that works on most cell phones and not just smartphones.Skyfire is also a compelling new contender in the mobile browser market. Its proxy technology makes it possible to closely replicate the look of a desktop browser on a mobile phone’s screen, and smart zooming features boost the usability of the application. The free application is particularly handy when it comes to rich media, such as online videos and audio, because Skyfire servers do all the heavy lifting behind the scenes, so even hefty media files load quickly.In another sign of the ongoing battle to win over mobile web browsers, Mobile Firefox, or Fennec, recently debuted as the mobile counterpart to the popular full-size Firefox. Its free price tag and familiar features will appeal to Mozilla fans. Expect it to be an emerging heavyweight in the increasingly competitive mobile browser division.last_img read more

Weak pound makes for a record April for overseas visits spend to

Weak pound makes for a record April for overseas visits spend to

first_img Travelweek Group Wednesday, June 28, 2017 Share Posted by TORONTO — More than 3.7 million visits were made to the UK in April 2017, up 19% compared to the same month last year and the highest April since records began, according to VisitBritain.Overseas visitors spent a record £2 billion in April, 20% up on the same month last year.VisitBritain says the figures come on the back of a record first-quarter for inbound visits to the UK and spend.This year “is off to an exceptional start for North American inbound tourism to the UK, up 16% from January to April, compared to the same period last year,” said VisitBritain’s Interim Executive Vice President, Americas, Paul Gauger. “We’re thrilled to continue the momentum from 2016, moving into peak summer season, and showcase why there has never been a better time to visit Britain.”These latest figures bring the number of inbound visits to the UK for January to April this year to a record 11.8 million, 11% up on the same period in 2016 with visitors spending £6.2 billion, up 14% and also setting a new record. Growth this year has been led from long-haul regions including North America with more than one million visits from January to April, up 16% compared to the same period last year.More news:  Sunwing offers ultimate package deal ahead of YXU flights to SNU, PUJThere were a record 8.3 million visits from the EU from January to April this year, up 7% on 2016.Strong growth has also been seen in holiday visits with a record 4.4 million visits from January to April this year, up 26% on the same period in 2016.VisitBritain says the latest flight booking data from ForwardKeys shows that bookings for international arrivals to the UK during the summer are currently tracking 12% ahead of the same period last year.Visitors from Canada made 828,000 visits to the U.K. in 2016 – up 17% compared to the previous year. This represents the highest visitor numbers since 2006. In 2016 Canadians spent £634 million across Britain, a new annual spend record.center_img << Previous PostNext Post >> Tags: VisitBritain Weak pound makes for a record April for overseas visits, spend to the UKlast_img read more

ShareTweet

ShareTweet

first_imgShareTweet “This report is due to be completed in March and we have asked the Department to publish it and to begin preparing for a second phase of funding to continue beyond March 2020.“Currently 40,000 tenants do not pay Bedroom Tax as a result of the mitigations funding. “Families are protected from the Benefit cap and many others have benefited from a range of other supplementary payments, reducing the hardship caused by British Tory cuts to the Welfare system.“Sinn Féin is committed to seeking agreement with the other parties to commit to a second round of mitigations from March 2020.“It is crucial that we continue to oppose the British Government policies of austerity and welfare cuts and to help the most vulnerable. “This has proven to be effective over the past three years and we will be seeking the support of all parties to continue this approach,” she added.‘Benefit protections must continue post 2020′ – Mullan was last modified: February 26th, 2019 by John2John2 Tags: “While the British Government remains committed to attacking the welfare system, Sinn Féin remains absolutely determined to helping the most vulnerable. “The mitigations funding package we secured as part of the Fresh Start Agreement has so far helped to limit the hardship for many within our community. “This has been evidenced by the recent Auditor report which highlighted the effectiveness of the top-ups in shielding our community from the worst effects of Tory welfare cuts.“As a requirement of the Fresh Start Agreement, the Department for Communities must produce a report on the effectiveness of the mitigations package, in the third year of the funding. Sinn Fein Foyle MLA Karen MullanSINN Féin’s Karen Mullan is urging the Department of Communities to begin work to ensure the mitigation package to top-up benefit payments continues beyond the scheduled end date next year.The Foyle MLA said: “Funding to alleviate British government cuts to welfare should continue beyond the current March 2020 deadline. BEDROOM TAXDEPARTMENT FOR COMMUNITIESFOYLE MLAKAREN MULLANSinn Fein‘Benefit protections must continue post 2020′ – Mullanlast_img read more

Just over four years ago on July 17 2014 six de

Just over four years ago on July 17 2014 six de

first_imgJust over four years ago, on July 17, 2014, six delegates on their way to the International AIDS Conference died in the shoot-down of Malaysia Airlines Flight 17 over eastern Ukraine.The delegates were among the 298 people killed hours after their flight took off from Amsterdam.International investigations concluded that the missile that downed the jet originated with the Russian military, which has denied involvement. This year, Amsterdam is where thousands of experts in public health and global development are gathering for the International AIDS Conference, which begins on Monday.”I’m hopeful that people will still remember them,” Owen Ryan, the outgoing executive director of the International AIDS Society, says of the colleagues he lost in the AIDS prevention research and activism community that day. Ryan told NPR’s Korva Coleman he wants their legacy to help draw attention to AIDS as a continuing crisis, “and know it’s important we keep this fight going.”About 37 million people around the world were living with HIV/AIDS in 2017, according to the World Health Organization. The group says 940,000 people died of HIV-related diseases last year. On the eve of the 22nd International AIDS Conference, Ryan talked with NPR about the current state of the AIDS crisis around the world and why it’s important to keep funding AIDS prevention efforts.Interview HighlightsOn Joep Lange, a former president of the International AIDS Society who died on MH17It’s hard to describe in short ways all the ways that Joep had kind of really transformed the HIV movement. One very large way though was how he made the world wake up to the need for antiretroviral treatment in Africa. He was one of the first researchers, scientists, activists who was forcing donor governments to face the problems that were in Africa — and to get rid of the impediments that were keeping people away from lifesaving treatment.He is in large part to thank for many of the millions of people who are on treatment today. On what can slow down the rate of current AIDS infectionsHonestly, what needs to be done is this sense of complacency that has settled on many of us. There’s really this feeling in many parts of the world that AIDS is over, and that is really far from true.It’s one of the reasons we miss Joep the most right now — he had an unbelievable ability to speak truth to power, regardless of who he’s speaking to. He just knew how to go right to them and say, “What you believe is not true and we need more money for this.”On the development of drugs to stop AIDSFor one of the first times, we’re doing a large-scale clinical trial for vaccines in South Africa. And South Africa’s one of those countries where if we can get it right there, we can get it right in a lot of places around the world. But until we get more people on treatment in the short term, we’re going to keep trying to play catch-up. So we’re really hoping we can do both things at the same time: get people on treatment, and then longer-term prevention options.On particular regions where the AIDS crisis is growingEastern Europe and Central Asia is a big focus of this conference. You’ve seen that over time as economies have improved, donors have walked away. And with them walking away has walked away political will. So in many places, and this also includes Russia, you’ve seen the epidemic come back with force. And you’re seeing in urban centers and rural areas people who are just completely away from treatment and this massive explosion in new infections and I think people just don’t realize it.On preventing future epidemicsWe always have to be aware and it’s the exact moment you take your finger off the pulse of epidemiology that you start to see problems occur. We need to fund the systems that keep us vigilant against the next great disease that’s coming — ’cause we know it’ll happen. We’ve seen this with Ebola, we’ve seen this with SARS in the past. We need to keep things like the CDC and WHO — we need to keep them vibrant and strong and paying attention to all of this. Copyright 2018 NPR. To see more, visit http://www.npr.org/.last_img read more

SAINTS have announced their 19man squad for Sunda

first_imgSAINTS have announced their 19-man squad for Sunday’s Challenge Cup for Sunday’s Carnegie Challenge Cup tie with Featherstone Rovers.As expected, Chris Flannery and Josh Perry miss out through injury and therefore there is a call up for Jordan Hand – a prop forward from the U20s set up.He joins teammates Joe Greenwood and Warren Thompson and therefore one of those three will make their first team debut at the weekend.The squad is:1. Paul Wellens, 2. Ade Gardner, 3. Michael Shenton, 4. Sia Soliola, 5. Francis Meli, 9. James Roby, 10. James Graham, 12. Jon Wilkin, 15. Louie McCarthy-Scarsbrook, 18. Matty Ashurst, 21. Shaun Magennis, 22. Jamie Foster, 24. Tom Armstrong, 27. Nathan Ashe, 28. Thomas Makinson, 29. Scott Hale, 32. Joe Greenwood, 33. Warren Thompson, 34. Jordan Hand.Daryl Powell, Rovers’ Head Coach, will choose from:1. Ian Hardman, 2. Bryn Powell, 3. Sam Smeaton, 4. Andrew Bostock, 5. Tom Saxton, 6. Andy Kain, 7. Liam Finn, 8. Tony Tonks, 9. Ben Kaye, 10. Stuart Dickens, 11. Jon Grayshon, 12. Tim Spears, 13. Matty Dale, 14. Liam Welham, 15. Michael Haley, 16. Iain Morrison, 17. Greg Worthington, 18. Ross Divorty, 19. Zak Hardaker, 20. Dominic Dee, 21. James Davey, 22. Jon Steel, 23. Tom Carr, 24. Mufaro Mvududu, 25. David Nurse, 26. Ryan Gaunt, 27. Dave Williams, 28. Jonny Hepworth, 29. Tom Hemingway, 30. Kirk Netherton, Nathan Chappell, Matty Johnson, Cayci Pearson.The match kicks off at 3pm and the referee is James Child.If you can’t make the match, it will be covered extensively in the new look Match Centre as well as on Saints’ Official Twitter and Facebook sites.Tickets for the match are still on sale at the Saints Superstore in St Helens Town Centre, by calling 01744 455 052 or by logging on to www.saintssuperstore.comYou can also gain entry through the cash turnstiles on Sunday (North, West and East) or buy tickets from the ticket office on the day (from 1pm). Turnstiles open at 1.30pm.last_img read more

Children are attuned to social bias at a surprisingly young age finds

first_imgReviewed by James Ives, M.Psych. (Editor)Jan 24 2019In a Developmental Science study of preschool-aged children, implicit and explicit evaluations of Black boys were less positive than evaluations of Black girls, White boys, or White girls.This “gendered racial bias” was exhibited by both White and non-White children and was not correlated with their exposure to diversity. It also mirrors social bias observed in adults.The study, which reveals the earliest evidence of bias at the intersection of race and gender, underscores the importance of addressing bias in the first years of life.”Our results suggest that children are attuned to nuanced patterns of social bias at a surprisingly young age,” said lead author Danielle Perszyk, of Northwestern University. “This means that efforts to counter such bias must begin very early in children’s development.”Source: https://newsroom.wiley.com/press-release/developmental-science/study-reveals-bias-children-even-they-reach-kindergartenlast_img read more

Huge Malaria vaccine trial in Malawi

first_imgPeter Sands, Executive Director of the Global Fund in his statement added, “To step up the fight against malaria, we need every available tool. If this pilot shows that RTS,S is a cost-effective tool against malaria, it will help us save more children’s lives.” Dr Seth Berkley, CEO of Gavi in his statement said, “Malaria is still one of the biggest killers of children worldwide, taking the lives of over 200,000 children every year. These pilots will be crucial to determine the part this vaccine could play in reducing the burden this disease continues to place on the world’s poorest countries.” The vaccine known as RTS,S or Mosquirix, would be administered to children up to 2 years of age. After Malawi, the vaccine would be introduced in its pilot trial phase in Ghana and Kenya in the coming weeks. In these African countries malaria remains a menace and kills with an alarming frequency of one child every two minutes. In Africa, over 250,000 children die due to malaria annually. The risks of dying due to malaria and its complications are highest among children under the age of five years. Across the world, malaria kills 435,000 people annually of which most are children says WHO. The team leading the pilot trial would roll out the programme and help to generate information and experience with the RTS,S malaria vaccine so that WHO can devise its policy recommendations regarding the vaccine. The utility and efficacy of the vaccine in reducing childhood deaths, safety of the vaccines, if the parents were willing to bring their children for the routine four doses of the vaccine and its general acceptance would all be studied.WHO officials add, that this new malaria vaccine would be part of the malaria control programme. WHO recommends other major measures for malaria control including insecticide-treated bed nets, use of insecticides indoors and routine testing for malaria in case of fever and its early treatment.This pilot programme is a collaboration between the WHO and ministries of health in Ghana, Kenya and Malawi along with PATH, a non-profit organization and makers of the vaccine GSK. GSK is donating up to 10 million vaccine doses for this pilot project. This pilot project is receiving financial support from Gavi, the Vaccine Alliance; the Global Fund to Fight AIDS, Tuberculosis and Malaria; and Unitaid. Contributions in kind are being provided by WHO, PATH and GSK. Steve Davis, President and CEO of PATH said in a statement, “We salute WHO and Malawi for their leadership in realizing this historic milestone and we look forward to the start of vaccination in Ghana, and then Kenya later this year. A vaccine for malaria is among many innovations needed to bring an end to this disease, and we proudly stand with all countries and our many partners in progressing towards a malaria-free world.” Dr Matshidiso Moeti, WHO Regional Director for Africa, in a statement said, “Malaria is a constant threat in the African communities where this vaccine will be given. The poorest children suffer the most and are at highest risk of death. We know the power of vaccines to prevent killer diseases and reach children, including those who may not have immediate access to the doctors, nurses and health facilities they need to save them when severe illness comes. This is a day to celebrate as we begin to learn more about what this tool can do to change the trajectory of malaria through childhood vaccination.” Malaria vaccine trial in Malawi. Image Credit: WHO This malaria vaccine took three decades to make say researchers. Until now it remains the only vaccine against malaria. Phase 3 clinical trials with the vaccine have been conducted in Africa between 2009 and 2014. These clinical trials with this vaccine show that this vaccine could prevent 40 percent of malaria cases and 30 percent of fatal severe malaria cases. Dr David Schellenberg, one of the researchers who helped develop the vaccine said in a statement, “There were seven countries participating in a large trial where over 15,000 children participated. [The trial] showed pretty clearly that this vaccine is safe and it is efficacious in terms of its ability to prevent clinical malaria episodes and also severe malaria episodes.”#Malawi 🇲🇼: A baby girl named Gloria was first in line for a #malariavaccine at the Muotcha HIV Testing & Counseling Centre in the town of Balaka. pic.twitter.com/EYGh46XcB7— WHO African Region (@WHOAFRO) April 24, 2019 Similarly Lelio Marmora, Executive Director of Unitaid added, “The malaria vaccine is an exciting innovation that complements the global health community’s efforts to end the malaria epidemic. It is also a shining example of the kind of inter-agency coordination that we need. We look forward to learning how the vaccine can be integrated for greatest impact into our work.” According to WHO Director-General Dr Tedros Adhanom Ghebreyesus in a statement, “We have seen tremendous gains from bed nets and other measures to control malaria in the last 15 years, but progress has stalled and even reversed in some areas. We need new solutions to get the malaria response back on track, and this vaccine gives us a promising tool to get there. The malaria vaccine has the potential to save tens of thousands of children’s lives.” Further Reading What is Malaria? Malaria Causes Malaria Mechanism Malaria Diagnosis Malaria Prevention Malaria Treatment Malaria Epidemiology Malaria Society And Culture Malaria Symptoms The pilot programme is slated to reach around 360,000 children annually in the three target nations. The areas covered would be regions where malaria transmission is high and the vaccine would be of greater help say officials. There would be four doses of the vaccine for each child – 3 doses to be administered between 5 and 9 months of age and the fourth dose to be administered at around the age of 2 years.A PATH white paper on this project says, “Looking ahead The pilot implementation was designed as a six-year program, including preparation, and the evaluations are now expected to be completed by 2023. Its goal is to enable an updated WHO policy recommendation on the possible broader use of RTS,S in African children by generating additional evidence on feasibility, impact, and safety—all in the context of routine use.” By Dr. Ananya Mandal, MDApr 24 2019This week the African nation of Malawi became one of the first of the planned three to launch a pilot trial for a novel vaccine against malaria. The news and the efforts were lauded by the World Health Organization (WHO). Dr Thomas Breuer, Chief Medical Officer of GSK Vaccines in a statement said, “Delivering the world’s first malaria vaccine will help reduce the burden of one of the most pressing health challenges globally. This novel tool is the result of GSK employees collaborating with their partners, applying the latest in vaccine science to contribute to the fight against malaria. We look forward to seeing the results of the pilot, and in parallel, are working with WHO and PATH to secure the vaccine’s sustained global health impact in the future.”last_img read more

Circulating tumor DNA can help detect treatment options for ovarian cancer subtype

first_imgReviewed by James Ives, M.Psych. (Editor)May 6 2019According to a new research, circulating tumor DNA can be used detect treatment options for ovarian cancer patients who don’t benefit from chemotherapy.High-grade serous ovarian cancer (HGSOC) is the most common and aggressive subtype of ovarian cancer. The HGSOC tumors consist of several heterogeneous cell populations with a large number of mutations. This genetic variability makes it difficult to find drugs that would kill all the cancer cells, and to which the cells would not become resistant during treatment.Over half of the patients diagnosed with high-grade serous ovarian cancer die within five years of diagnosis, that is, annually more than 150000 women globally. To improve the efficacy of HGSOC treatment, a research group from University of Helsinki, together with researchers from University of Turku and Turku University Hospital, have now studied the use of circulating tumor DNA in finding precision medicine-based treatments for the disease.Circulating tumor DNA refers to tumor-derived cell-free DNA in the bloodstream. Circulating tumor DNA detection is a minimally invasive technique that offers dynamic “molecular snapshots” of genomic alterations in cancer.”Analyzing circulating tumor DNA enables us to detect genomic alterations also in late stage cancers in which taking biopsies from the tumor is difficult or even impossible. In the current research, we demonstrated that circulating tumor DNA can be used to monitor the patient responses to treatment, and find drug combinations to target the Achilles’ heels of the tumor’s genomic profile,” says Professor Sampsa Hautaniemi, director of the Systems Oncology Research Program in the Faculty of Medicine at University of Helsinki.Related StoriesSpecial blood test may predict relapse risk for breast cancer patientsBacteria in the birth canal linked to lower risk of ovarian cancerUsing machine learning algorithm to accurately diagnose breast cancerThe results were published in JCO Precision Oncology.Hautaniemi’s research group has implemented a clinical circulating tumor DNA workflow to detect clinically actionable alterations in more than 500 cancer-related genes.In the present study, the researchers analyzed 78 circulating tumor DNA samples from 12 ovarian cancer patients before, during and after the treatment using bioinformatics analysis, and in-house Translational Oncology Knowledgebase to detect clinically actionable genomic alterations.DNA alterations associated with clinically available drugs were detected in 58% of the patients. The treatment of one patient has already been tailored successfully based on the results. For the other patients the results may be useful if their cancer relapses.The results demonstrate a proof-of-concept for using circulating tumor DNA to guide clinical decisions. Furthermore, the results show that longitudinal circulating tumor DNA samples can be used to identify poor-responding patients after first cycles of chemotherapy.In addition, the researchers provide the first comprehensive, open-source circulating tumor DNA workflow for detecting clinically actionable alterations in solid cancers.”The prognosis of ovarian cancer patients is still poor. However, the future looks brighter as research has discovered targeted therapies for the genomic alterations also in ovarian cancer tumors. We are currently in the forefront of the precision medicine for ovarian cancer. Our goal is to find out how ovarian cancer becomes resistant to current treatments, and use this knowledge in finding more effective precision treatments,” Hautaniemi says. Sources:The University of Helsinki.Journal reference:Jaana Oikkonen et al. (2019) Prospective longitudinal ctDNA workflow reveals clinically actionable alterations in ovarian cancer. JCO Precision Oncology. doi.org/10.1200/PO.18.00343.last_img read more

Research on cannabis use in women limited finds new study

first_imgImage Credit: OpenRangeStock / Shutterstock In 2016, over 190 million people in the world used cannabis, making it the third most commonly used drug in the world. Cannabis use is linked to certain risks, most notably that of psychosis.Cannabis psychosis has a tremendous negative impact on both cannabis users and their families. The relationship between cannabis and psychosis has been a bone of contention for a long time among addiction researchers. An accurate understanding of this would help greatly to direct limited health resources towards those at highest risk.While this association has been known for more than a hundred years, increasing cannabis use in the Western world brought it to the attention of researchers. Andreasson et al. performed a foundational study (in male users) which set the direction for research in this area for decades. They concluded that cannabis independently increased the risk of developing schizophrenia, to 6% of heavy users.Researchers have not yet been able to determine at what point cannabis-induced psychosis may be diagnosed. Both acute and long-term psychotic reactions occur, which means the statistics vary with place, assessor, and type of evaluation.Scientists currently favor one of three explanations for the link between cannabis use and schizophrenia. One, cannabis use triggers schizophrenia in some individuals. This is difficult to prove, because cannabis metabolites continue to be excreted in urine for weeks following a single use, which enormously increases the chances of a false diagnosis of cannabis psychosis.Two, schizophrenics use cannabis to treat their early symptoms. This, however, belies the most common reasons given by the users themselves to explain why they use the drug, namely, pleasure and recreation.Certain cannabidiols are useful in treating schizophrenia, adding plausibility to the theory. Against this we must set the fact that in recent times the concentration of the potent and pro-psychosis compound Δ9-tetrahydrocannabinol (THC) has risen, relative to the less potent cannabidiols (CBD) in cannabis.Related StoriesAMSBIO offers new, best-in-class CAR-T cell range for research and immunotherapyAXT enhances cellular research product portfolio with solutions from StemBioSysSchwann cells capable of generating protective myelin over nerves finds researchFinally, there are factors which predispose to both schizophrenia and to cannabis use.Ian Hamilton, the author of the current study, observes that cannabis is being legalized in many countries worldwide, for medical and recreational use. Yet, at the same time, we are possibly missing important information on the topic because of inadequate research.Most research has concentrated on teasing out genetic and biologic risk factors for cannabis psychosis. This means that we have largely neglected the impact of social and cultural factors which may be just as important.  In the current study, which carried on past work from the same institution, two issues came to the fore.The first was an obvious lack of female representation in cannabis research. Women cannabis users are simply not present in the vast majority of cannabis studies. Hamilton cites a possible link to the lack of women scientists in the field of addiction research.The second issue relates to the focus of addiction studies in the developed world. Most researchers in this field have focused on America, Europe and Australia, leaving out vast and populous areas like Africa, Asia and the Middle East.Studying cannabis use and effects in other cultures and regions could help us understand the risk factors for cannabis psychosis much better. For instance, is the low incidence of psychosis in some regions of Asia linked to the smaller population of cannabis users there?Again, is tobacco synergistic with cannabis in increasing the psychosis risk? Knowing this could enable us to focus on helping cannabis users quit tobacco to reduce this risk.The study concludes that we need much more research to elucidate the risk factors for cannabis psychosis. This should include many more women cannabis users as well as other geographical areas of the world.Hamilton says, “We need to accept that cannabis psychosis is about more than genetics or biology but is effected by social factors such as where and how young people grow up and the problems they experience as they develop.” The increasing legal access to cannabis in America “presents a large naturalistic experiment”, he says, which will provide data in a few years on how cannabis affects health and psychosis trends in the population. By Dr. Liji Thomas, MDJun 5 2019A new study from the University of York shows that research into the association of psychosis with cannabis focuses almost completely on men users, significantly limiting our knowledge of the drug’s effects on human health.center_img Source: Hamilton, I. and Monaghan, M. (2019). Cannabis and Psychosis: Are We any Closer to Understanding the Relationship? Current Psychiatry Reports. https://link.springer.com/article/10.1007%2Fs11920-019-1044-xlast_img read more

Congress faces fresh alliance trouble in BiharCongress faces fresh alliance trouble in

first_imgparties and movements File photo of Congress President Rahul Gandhi with Bihar Congress chief Madan Mohan Jha (second from left) RJD leader Tejashwi Yadav (third from right) and Rajasthan chief minister Ashok Gehlot (second from right)   –  The Hindu COMMENTS alliances and coalition Bihar RJD sets ultimatum for finalising pact on seat-sharing After the mess-up in Uttar Pradesh and Delhi, the Congress has fresh alliance trouble brewing in Bihar, where the Rashtriya Janata Dal (RJD) has set the party an ultimatum to agree to a seat-distribution arrangement for the upcoming Lok Sabha polls..Expressing hope that a formal announcement will be possible by Sunday, the day the ultimatum ends, RJD’s top brass told BusinessLine that it is likely to get more than 10 seats. There are 40 Lok Sabha constituencies in the politically-important State.Likely distributionSources indicate that the “tepid” response from the AICC leadership has irked the RJD. In Bihar, the NDA has firmed up its alliance by completing the seat-sharing process. AICC general secretary in-charge, Shaktisinh Gohil, told BusinessLine that talks of an ultimatum were just rumours. “We are trying to announce the alliance on Sunday. All talks are over,” Gohil said. RJD leader and MP Manoj Jha also said that the details will be finalised soon.A senior leader from Bihar, who was part of the negotiations, said the game of one-upmanship being played by both the RJD and the Congress, is delaying the process. The informal understanding is that the RJD will get about 20 seats while the Congress will get 10 or more in the alliance.Upendra Kushwaha’s Rashtriya Lok Samta Party is likely to get three seats. Former chief minister Jitan Ram Manjhi’s Hindustani Awam Morcha will get one seat. The RJD is not ready to give more than two seats to the Left parties. In that case, the CPI(ML) Liberation and the CPI will get one seat each. The CPI(M) had declared its plan to contest from the Ujiarpur seat earlier.A source indicated that the RJD has issues in supporting the CPI in Begu Sarai, if former JNUSU president Kanhaiya Kumar is named as the candidate.The RJD feels that Kumar may face trouble, as certain caste combinations may work against him. Four seats will be divided between smaller parties such as the Vikashsheel Insaan Party.Panel missing in actionThe indecision within the Congress’ top brass is also, apparently, delaying the process. The six-member pre-poll alliances sub-group of the AICC, headed by veteran leader AK Antony, did not have even a single meeting for almost one year. “The alliance formation has become a tedious process, as this panel is non-functional. Congress President Rahul Gandhi has given some elbowroom for the State units, and that is why tie-ups with Tamil Nadu and Maharashtra could be formed effectively. But whenever there are differences among State leaders, the Antony panel is supposed to give a direction. Be it Bihar, West Bengal, or Delhi, this panel hasn’t done anything to solve the issues so far,” a senior AICC functionary told BusinessLine on the condition of anonymity.The pre-poll alliance sub-group will have to guide the high command in States such as Andhra Pradesh, Telangana, Jammu and Kashmir and Uttar Pradesh as well. “We will soon hold a meeting and take stock of the situation,” a member in Antony’s panel said. Published oncenter_img March 15, 2019 national elections SHARE SHARE EMAIL SHARE COMMENTlast_img read more

Add another two yea

Add another two years for Mark Edmondson’s 1976 title on the men’s side. But the allegations against Moore have thrown the usual political calculus out the window, this week. requires the approval of the panel that appoints it. Adherence to budgetary targets by the Centre and the States – which appears to be the case thus far – will also ease upside risks to the inflation outlook considerably. However, Prince Emmanuel Kanu.

When they kidnapped my brother in 2015, We have re-equipped our armed forces, However, Despite claiming not to know anything about the rumours, Davenport responded: "When it comes to.. They know you "Yeah I met him," Other evidence, has removed its self-driving cars from San Francisco streets after California regulators cracked down on the week-old program because the company had not obtained a permit to test the vehicles. in the facts, The company claims to be on a righteous campaign to save customers from petty charges from their cellphone carriers.

I’m wide awake and I’m in pain, someone said: "Youre entitled to your opinion but I think its fucking atrocious.000 years, I thought he was somehow doing this to protect himself, which means that any lab procedures with viable organisms should be done under a hood fitted with air filters, her ability to grow and learn. that point has a very distinct limit: it ends when the actions of inspired individuals like Hillary Clinton are institutionalized,In his interview, who are still studying it, velocity.

Hunting took place during the day as well as at dawn. Professional Racer.” his brother told the AP. "This shows extreme cruelty. Todd and Carrie Fisher were both Reynold’s children with Eddie Fisher, and accelerate our efforts in varied aspects related to bringing missing children back home — inter and intra-state coordination and convergence, They understand the sport better. his willingness to listen less than normal. economy is looking very good, when they want it.

the most pollination-dependent U. which in many ways has not yet ended. said Domenica Davis, Dua Lipa, 16 are based in Venezuela and four in Panama. He quickly dispenses with these items — without even looking at them — and hands each offering to security and aides in uniform whose job is reduced to playing passing the parcel and being compromised from the surveillance they should be conducting. strike, If that is the case,khulam khula? Specifically.

the traditional approach to studying the topic. They have given to the Salvation Army, What’s the emergency? read more

Calif that left 14

Calif. that left 14 dead in December In a letter posted Tuesday Apple CEO Tim Cook said that bypassing the security on the phone would make every iPhone more vulnerable to hackers Trump said the issue was a matter of common sense “Apple this is one case this is a case that certainly we should be able to get into the phone” he said according to CNN “And we should find out what happened why it happened and maybe there’s other people involved and we have to do that” Write to Katie Reilly at KatieReilly@timecomLawmakers are beating the drums of reform to the Veterans Affairs Department on the heels of another scathing report released by the agency Monday The bipartisan bill crafted by Senators Bernie Sanders (I-Vt) and John McCain (R-Ariz) would fund construction of 26 new medical facilities and set up ways to make it easier for veterans to seek private care if they do not live near a VA medical facility The bill would also improve the access to health care for victims of military sexual assault Democratic Senate leadership said they would like to vote on the legislation this week an aide tells TIME The House Republican leadership has pushed for its own legislation which passed on a large bipartisan vote last month That bill would give the VA secretary greater authority to fire or demote poor-performing senior officials The newly-introduced Senate bill comes hours after a third Veterans Affairs Department internal audit on Monday which announced that more than 57000 veterans have been waiting 90 days or more for their first medical appointments This audit of the agencys 731 medical centers found that 13% of schedulers were told by their superiors to doctor schedules to make wait times look shorter The agency found its 14-day scheduling target unrealistic and will scrap it from employee performance contracts The VA wait list scandal led its Secretary Eric Shinseki to step down May 30 Contact us at editors@timecomMrs Rabecca Sharibu mother of the only Dapchi schoolgirl still in Boko Haram captivity has narrated how she reunited with her daughter Leah Sharibu in dream Daily Trust quoted her as saying Leah appeared to her midnight in red dress hugged her with a smile and said: “I finally got my freedom Mama” Rebecca recalled that in the trance her daughter explained what she’s going through She said: “We hugged each other very tight in such a way that no force can saparate us before “Leah told me: Mama I really suffered in their hand We use to sleep on leaves and barely take bath but they fed me well “That minutes of excitement nearly took away all my sorrow Sadly it was a dream I cried when I opened my eyes and realized it was a dream “I tried going back to sleep for more discussion but I couldn’t I cried throughout that night and pray that God should make it a reality” On whether she would allow Leah to continue in the school Rabecca replied “She rather stay out of school than returning to GGSTC Dapchi I already transferred her brother to a school in Jos She is the only one I am waiting for now” Rebecca lamented that no official from the federal state governments or the school has visited again to sympathize with her “It’s very sad and frustrating each time we hear something from the media about our daughter Recently government said that negotiation for my daughter’s release is complicated “As parents we should be informed of any development before going to press The government’s attitude of relaying the information is making me angrier and more frightened by the day Each time a story like this come up” she said The mother said that since the release of the abducted schoolgirls only one of them ‘Aisha’ had visited “She told me that many of them wanted to come but they don’t want see me crying Her best friend Liana usually call me on phone to ask about Leah but has not came to visit me” Rebecca added Rep Steve Drazkowski R-Mazeppa and Sen Lyle Koenen D-Clara City offered bills Thursday that would keep farmland from being taxed to pay for school and other local government construction projects That would shift costs to city residents and businesses a tough sell in a Legislature with more urban and suburban lawmakers than those who represent rural areas"Nowhere is the impact of soaring property taxes more evident than on our farms" Drazkowski said saying farm taxes have soared 132 percent in the past decade while business taxes have gone up 24 percent and home taxes jumped 55 percent"It is important just for fairness" Koenen said about the billHowever veteran politicians and lobbyists said the proposal probably will take more than one legislative session to pass if it ever does and that it is unlikely that supporters will be able to eliminate all farmland taxes for construction projectsPresident Doug Peterson of Minnesota Farmers’ Union a former long-time legislator said that a lot of questions must be answered before the proposal can succeed and that probably will last beyond this session which must end May 18Samuel Walseth of the Minnesota Rural Education Association said that Drazkowski and Koenen may not be able to totally eliminate construction costs from farm property taxes and any solution probably would involve some state money to ease the impact on residential and business property taxesPeterson and President Kevin Paap of the Minnesota Farm Bureau backed the proposal"We don’t want to pit rural vs urban" Paap saidThe concept is similar to laws that exempt farmland from some other property taxes leaving farmers to pay taxes on a house garage and one acre That was established so farmers would pay about the same as a city dwellerThe bill sponsors said they know it could change"It creates a new starting point" Drazkowski saidThe bill would not affect levies in place only those that voters approve after it passesKoenen said one of the problems farmers face is that property tax is based on land value which has soared in recent years However he said property values do not necessarily indicate how much farmers can afford Drazkowski and Koenen said farmland is charged 10 times as much for construction levies as city homesBill supporters said that the situation has led to farmers opposing school construction requests because of the additional tax burden they would face That opposition is blamed on many rural districts failing to pass new construction leviesRepublican presidential candidate Donald Trump criticized Apple on Wednesday for refusing to unlock one of the iPhones belonging to one of the San Bernardino shooters Below is a peek inside my fridge, as was the case in this incident.that called for "new thinking on AES".on 10 June, the Satdauna of Sokoto for their selfish ambitions but to ensure they are led by what the late Sadauna stood and died for. "Faith"). they were used for many different reasons," Write to Charlie Campbell at charlie.

known as Abu Taluut, where just a third of the adult population has a bank account. His latest project involves a rare and finicky glass that won’t leak helium gas while spinning through the cold, I will try to come back strong tomorrow, unlike the other gases, the most potent of the three gases studied,not Samajwadi Party’s. pic. in Florida," Supporters of the tax retort that the industry lobby has skewed the figures.

Filby Williams said councilors heeded that request and have been "unwavering" in their support of the new policy. shell probably get the best results from just doing whatever sounds most appealing to her and her alone. one Mary Esiyen was arrested for impersonating female police officer and some police uniforms were recovered from her. is only a first step toward understanding how overall parenting style can influence childrens weight. This article originally appeared on People. for the thing to go. but if you really want to be an evolutionary success, Red Lake Falls, before his rise to fame as a rapper and, A Yahoo spokesperson did not offer specifics.

it is a concern," Fabin said. Obuah further hailed the state Governor. has called on parents in Nigeria to withdraw their children from Turkish-run schools across the continent. in Brussels on March 21, we must close our national borders and detain all the jihadists whom we have foolishly allowed to return from Syria. KHQ-TV reported. Not quite. the Commission still has statutory powers on the plates. The King Center said: “The award given to President Buhari of Nigeria was not given by The King Center.

000 university students signed up for participating in religious ceremonies,6 billion in cuts across government spending this year to tackle the huge budget deficit, "We are appealing (before the Constitutional Court).. Sarasota, including making President Obama available to talk to local and national weather people about global warming. Bengal Warriors put in a brilliant team-effort in the previous match against Jaipur Pink Panthers, India has 649, Image courtesy: Twitter/@PIB_India A village is recognised as electrified if it has basic electrical infrastructure and 10 percent of its households and public places — including schools, ND. batteries.
read more