Twenty One Pilots The Strokes To Headline Lollapalooza Paris In July

Twenty One Pilots The Strokes To Headline Lollapalooza Paris In July

first_img Email Twitter https://twitter.com/lollapaloozafr/status/1088119305022119936 Twenty One Pilots, Strokes Top Lollapalooza Paris twenty-one-pilots-strokes-headline-lollapalooza-paris-july Lollapalooza Paris includes French cuisine, art shows, the Kidzapalooza festival-within-a-festival, as well as the Lolla Planète area dedicated to raising environmental consciousness. Children under 10 accompanied by a ticketholder get in free. Tickets go on sale at the festival website on Jan. 24. Recap: Lollapalooza 2018 With The Recording AcademyRead more Twenty One Pilots, The Strokes To Headline Lollapalooza Paris In July The lineup for the third annual Paris edition of Lollapalooza also includes the 1975, Bad Bunny, Martin Garrix, Jain, and Eric PrydzPhilip MerrillGRAMMYs Jan 23, 2019 – 5:19 pm Lollapalooza Paris is heading to the Hippodrome De Longchamp July 20–21 this summer with headliners Twenty One Pilots and The Strokes and GRAMMY winners on the bill for the two-day fest, in addition to Twenty One Pilots, include Clean Bandit and Ben Harper.The 1975 and Martin Garrix will also be playing at the third annual fest. GRAMMY nominees appearing include Bad Bunny, Jain and Eric Prydz. Of course part of the excitement will be getting to know less well known acts. A few that we’ve been following include Gryffin, Jaden Smith, Tash Sultana, and Alison Wonderland. Facebook News last_img read more

What Are Town Boards Committees Talking About Week of August 26 2018

What Are Town Boards Committees Talking About Week of August 26 2018

first_imgWILMINGTON, MA — According to the Wilmington Town Clerk’s calendar, below are the town and school board, committee and commission meeting scheduled for the week of Sunday, August 26, 2018.Sunday, August 26No MeetingsMonday, August 27The Wilmington Community Development Technical Review Team meets at 9:30am in Town Hall’s Room 9. Read the agenda HERE.Tuesday, August 28The Shawsheen Tech School Committee meets at 7:30pm in the John P. Miller School Committee Room at the Tech. Read the agenda HERE.Wednesday, August 29The Wilmington School Committee meets at 7pm in the High School’s Large Instruction Room. Read the agenda HERE.Thursday, August 30No MeetingsFriday, August 31No MeetingsSaturday, September 1No MeetingsAll meetings are open to the public unless noted.(NOTE: While unlikely, it is possible additional meetings could be added to this week’s calendar on Wednesday, Thursday, or Friday.  It’s best to check the Town Clerk’s calendar mid-week.)Like Wilmington Apple on Facebook. Follow Wilmington Apple on Twitter. Follow Wilmington Apple on Instagram. Subscribe to Wilmington Apple’s daily email newsletter HERE. Got a comment, question, photo, press release, or news tip? Email wilmingtonapple@gmail.com.Share this:TwitterFacebookLike this:Like Loading… RelatedWhat Are Town Boards & Committees Talking About? (Week of August 25, 2019)In “Government”What Are Town Boards & Committees Talking About? (Week of August 18, 2019)In “Government”What Are Town Boards & Committees Talking About? (Week of June 23, 2019)In “Government”last_img read more

Virtual reality game Beat Saber reaches licensing deal with Imagine Dragons

first_img Oculus Virtual Reality Review • Oculus Quest is amazing, even months later Gaming Culture Tags The 10-track Imagine Dragons Music Pack will be available across major platforms like Oculus Quest and Rift.  Beat Saber Imagine Dragons fans and VR gaming nerds could soon be attending the same parties.Beat Saber, an award-winning virtual reality game, will get an Imagine Dragons music pack, Beat Games said Monday. The fast-paced music rhythm game is currently available on major VR platforms, such as Facebook’s Oculus Quest and Rift devices.The announcement of the expansion pack comes as the Electronic Entertainment Expo, or E3, gets underway in Los Angeles. The conference is the video game industry’s biggest event of the year, with updates on major game franchises and consoles. Oculus will demonstrate a new 360-degree level that features the Imagine Dragon’s hit “Believer.” A 360-degree level allows the user to look in all directions of their simulated environment as they would in real life. The 10-track music pack includes songs from the Grammy-winning band’s Night Visions, Smoke + Mirrors, Evolve and Origins albums. The addition of Imagine Dragons songs marks the first time major labels have partnered on an expansion pack for the VR game. Imagine Dragons is on the KIDinaKORNER and Interscope Records labels. Players can buy songs individually for $1.99 apiece or purchase the entire package for $12.99. The pack, which goes on sale Monday at 9:15 a.m. PT, will be available on all major VR platforms.  CNET may get a commission from retail offers. In the game, players wear VR controllers and slash beats that zoom towards them. A VR headset uses two small lenses to focus images for players and immerse them in the game experience. Players slash red blocks with their left hands and blue ones with their right hands. The game uses music and visual effects to build excitement and has been compared to the VR versions of Guitar Hero or Just Dance. $398 News • Oculus Quest may have its first killer app with Beat Saber See it 0 Oculus Quest Post a comment Mentioned Above Oculus Quest Share your voicelast_img read more

Thai Airways to investigate tyre burst at HSIA

Thai Airways to investigate tyre burst at HSIA

first_imgAll tyres of the right wheel of a Thai Airways plane blast during landing at Hazrat Shahjalal International Airport in Dhaka on Tuesday. Photo: Collected/Prothom AloThai Airways will conduct an investigation into the incident of tyre burst on landing by one of its flights at Hazrat Shahjalal International Airport (HSIA) in Dhaka on Tuesday, reports UNB.”THAI will conduct an investigation as to the cause of the incident. THAI do apologize to all passengers for any inconvenience this may cause,” said the Thai Airways International Public Company Limited (THAI) in a statement.Flight Lieutenant Pratana Patanasiri, THAI vice president, Aviation Safety, Security and Standards Department said the flight TG321, operated with Boeing 777-200 aircraft, departed from Bangkok Suvarnabhumi Airport to Dhaka at 10.35 hours and arrived in Dhaka, at 12.10 hours (local time).”During touchdown at Hazrat Shahjalal International Airport (HSIA) there was heavy rain,” reads the statement shared on its verified Facebook page.Captain of the flight found out that the aircraft’s tyres had burst and the captain took control of the aircraft until it landed safely.The aircraft carried 172 passengers and 14 cabin crew. All the passengers and crew were safe with no injury.The company urgently replaced spare parts necessary for the full operation of the aircraft and accommodated passengers who booked to travel on the return flight TG322 from Dhaka to Bangkok on Wednesday with a larger aircraft, Boeing 777-300.last_img read more

Bank official killed in road crash

Bank official killed in road crash

first_imgA senior bank official was killed and two others injured as a speeding bus hit a CNG-run auto-rickshaw carrying them at Dewanhat area under Double Mooring police station in the port city of Chattogram on Wednesday morning, reports UNB.The deceased is Anwarul Azim, 56, assistant vice-president of Islami Bank Khatunganj branch and a resident of Haitkandi area in Mirsharai upazila.The accident took place when Anwarul along with one of his colleague was going to his office around 10am, said sub-inspector Alauddin Talukdar of Chittagong Medical College Hospital (CMCH) police outpost quoting family members.The bus hit the auto-rickshaw while crossing the Dewanhat flyover, leaving them critically injured.Physicians declared Anwarul dead at noon when he was taken to CMCH while his colleague Shaidul Islam, 45, and CNG driver Jahir Uddin,40, are undergoing treatment at the hospital, the SI added.last_img read more

Cardinals at No 9 in Collegiate Baseball Newspaper Preseason Poll

first_imgFOLLOWING THE CARDINALS ON SOCIAL MEDIAFans can follow Louisville baseball on Twitter at @UofLBaseball and on Facebook at http://www.facebook.com/ulbaseball. 2019 Collegiate Baseball Preseason Top 40 Print Friendly Version Story Links LOUISVILLE, Ky. – The University of Louisville baseball program will enter 2019 in a familiar place after landing at No. 9 in the Collegiate Baseball newspaper preseason poll released Tuesday.The announcement marks the 12th consecutive year (2008-2019) the Cardinals have earned a preseason national ranking extending their school record streak. Tuesday’s preseason poll extended another historic run for Louisville, which has remained ranked in at least one major national poll every week since the release of the 2012 preseason rankings — the longest such span in school history.Atop the Collegiate Baseball preseason poll is LSU while No. 2 Vanderbilt, No. 3 UCLA, No. 4 Texas Tech and No. 5 Stanford round out the top five. The Cardinals are among eight ACC programs in the top 40 joining No. 8 North Carolina, No. 10 Florida State, No. 15 Clemson, No. 17 Georgia Tech, No. 20 Duke, No. 22 NC State and No. 33 Miami.Last season, Louisville registered a 45-19 record overall after advancing to the championship round of an NCAA Regional for the seventh straight season. The Cardinals were ranked as highly as 23rd by Collegiate Baseball newspaper while also landing at No. 25 in the USA Today Top 25 and 27th in the National Collegiate Baseball Writers Association poll. Louisville registered its seventh straight 40-win season and the 11th in 12 seasons under head coach Dan McDonnell.Led by the return of All-American first baseman Logan Wyatt and All-ACC standouts Nick Bennett (LHP), Bobby Miller (RHP) and Danny Oriente (OF/DH), the Cardinals are scheduled to open the 2019 season against UConn with a three-game series on Feb. 15-17 at Joker Marchant Stadium in Lakeland, Florida, the spring training home of the Detroit Tigers. Louisville’s home-opener at Jim Patterson Stadium is set for Feb. 20 at 3 p.m., ET against Eastern Kentucky.2019 LOUISVILLE BASEBALL SEASON TICKETSAfter one season of ticketed admission for all home games, the Cardinals are giving free admission back to the fans in 2019. Louisville’s 15 ACC games as well as non-conference games against UK and Vanderbilt will be ticketed events at Jim Patterson Stadium. All other non-conference matchups, including games against Ole Miss, Western Kentucky and Xavier, will have free admission.The 2019 reserved chairback ticket packages, which include one ticket to each of the 17 ticketed games, are priced at $110 for adults, $90 for senior adults/youths and $90 for families of four or more. Season tickets for the Left Field Berm are also available at $50 per ticket. Season tickets are on sale now and can be purchased online here, by calling 502-GO-CARDS or by visiting the Louisville Cardinals Ticket Office, located near Gate 2 at Cardinal Stadium (2800 South Floyd Street) on weekdays from 9 a.m., until 5 p.m., ET. Complete details on 2019 UofL baseball tickets can be found at gocards.com/bsbtickets.last_img read more

SelfHealing Sunlight Helps Scratches on Cars Electronics and Furniture Disappear

SelfHealing Sunlight Helps Scratches on Cars Electronics and Furniture Disappear

first_img This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. (PhysOrg.com) — There are few things in life that are more annoying than having your iPod’s beautiful face marred by scratches. But what if those scratches could “heal” themselves? New technology developed at the University of Southern Mississippi could lead to just that situation. And it would work on more than just your handheld music device: Scratches on furniture and cars could disappear as well. It isn’t magic, though. In order to protect your merchandise from scratches, it would be necessary to coat them with a special polyurethane treatment. The coating is clear, and its special properties are derived from chitosan. Chitosan is the material that makes the exoskeletons of such creatures as crustaceans and insects hard. The chitosan is combined with oxetane. Oxetane is ring-shaped — and unstable. This becomes important for the healing of scratches. When something scratches the coating, the oxetane ring is broken. The reactive ends of the broken rings are eager to re-bond to something. The ultraviolet rays of the sun act as an activation mechanism for the chitosan. The chitosan binds the molecule fragments together, closing the ring again and helping the scratch to “heal”. The scratch appears to have disappeared, leaving the surface smooth once more. The process takes about half an hour in natural sunlight.This new advance is significant because creating non-living coatings that can repair themselves is tricky work. From expandable gel to nanoparticles, the quest for a coating that heals its own scratches has come up short. The latest attempt, though, seems a little more promising. It combines natural sunlight with a substance that occurs naturally in nature. Bio-mimicry continues to provide interesting answers to perplexing problems of science and technology, and the use of chitosan as part of a self-healing polymer is another example.The coating isn’t quite ready for commercial use, however. There is no answer to what happens when a second scratch is made over the position of the first scratch. And what happens if you have intersecting scratches? Nevertheless, there is tremendous potential for this coating.© 2009 PhysOrg.com Explore further Citation: Self-Healing: Sunlight Helps Scratches on Cars, Electronics and Furniture Disappear (2009, April 2) retrieved 18 August 2019 from https://phys.org/news/2009-04-self-healing-sunlight-cars-electronics-furniture.html ‘Crabby’ compound that skewers bacteria could prevent medical implant infections Will the iPod be able to heal itself of scratches? Image source: Goldmund100 via Wikimedia Commonslast_img read more

MCD dithers holds up National Intelligence Grid

MCD dithers holds up National Intelligence Grid

first_imgAs the Centre went about issuing an advisory on how to tackle terror in schools, its flagship intelligence security project – National Intelligence Grid (NATGRID), proposed after 26/11terrorist attack in Mumbai, got stuck in a land dispute between South Delhi Municipal Corporation and Delhi Development Authority. On Friday, the standing committee of the civic body refused to pass the layout plan of the NATGRID building and directed the municipal commissioner to approach Delhi High Court to safeguard its interests on the disputed land. Also Read – Need to understand why law graduate’s natural choice is not legal profession: CJI“We will pass the layout plan of the building only if the payment made by Union Ministry for Home Affairs to DDA is paid to South DMC plus annual ground rent of the proposed building or DDA must allot a similar 10 acre land at a suitable place to construct infectious disease hospital proposed by the corporation,” said Subhash Arya, chairman of the standing committee of South DMC and ‘referred back’ the matter. The 10 acre land which is part of a 22.15 acre plot of South MCD at Andheria More in Mehrauli was given to CRPF on rent to set up a temporary unit two years back. The price of the plot is estimated to be Rs 7.4 crore. Also Read – Health remains key challenge in India’s development: Kovind“Neither DDA nor Land & Building department could present any record but the officers of the ministry accepted the verbal claims of these agencies to accept the ownership of DDA on the land,”  said Manish Gupta in a written reply in the meeting. He further added that the decision of the Additional Secretary of Union Ministry for Urban Development Bhupendra Bahuguna to reject all their documents of ownership as ‘not credible’ was wrong and arbitrary. “We are ready to put all our records for forensic test,” Gupta said. Amid the furious debate on the issue the commissioner was pulled up by all  members of the standing committee cutting across party lines for his inability to present the matter to the ministry in a proper way.  Taking part in the debate leader of Opposition Farhad Suri said, “South MCD functions as per an act of parliament so we are equal to any central government agency. No one is above us but parliament,” said Suri. NATGRID was proposed in 2008 by the Union Ministry of Home Affairs and it approached South MCD in October 2013 to approve the layout plan of the building. After the new government took charge at the Centre it was expedited and three meetings were held between South MCD and NATGRID officers. On 7 October MHA asked South MCD to pass the layout plan ex post facto as the matter related to national interest and take the approval of the standing committee later but the civic body refused. On 14 October MUDS summoned a meeting of all the stakeholders and land ownership was decided in favour of DDA.last_img read more

M6 closed due to serious accident in West Midlands

first_imgGet the biggest Daily stories by emailSubscribeSee our privacy noticeThank you for subscribingSee our privacy noticeCould not subscribe, try again laterInvalid EmailThe M6 motorway is closed in the West Midlands following a ‘serious collision’ this evening. The accident has shut the southbound carriageway between J6 and J5 – with delays building. Three vehicles are believed to be involved, two lorries and a car, following the collision near Birmingham. Police and emergency services are at the scene as of 8.20pm on Thursday May 31 – and the motorway remains closed as of 11pm. A Highways England spokesman said: “The M6 in the West Midlands is currently closed between J6 and J5 while we assist Central Motorway Police Group and emergency services with a serious collision.” Traffic is currently queuing in the area, with reports of congestion stretching back to junction 7. Traffic England is currently suggesting motorists could consider the M6 Toll Road – and Highways England have now put a diversion in place (see below). We have no information yet on whether anyone has been injured. Trapped traffic is, as of 9.20pm, currently being released past the scene in lane one. A Highways England spokesman said: “Please be aware there is a lot of traffic to get through and we are going as quickly and safely as possible but this may take some time before you start to move.” The motorway is currently set to remain closed for several hours – with Traffic England currently estimating around midnight. In other traffic news nationally tonight, there is flooding on the A49 near Ludlow in Shropshire as heavy rain continues to batter the region. The M50 in Gloucestershire is also closed in both directions due to flooding. Read MoreYellow Weather Warnings for rain in force for Stoke-on-Trent until Friday night DIVERSION IN PLACE: Highways England have confirmed there is now a diversion in place following the collision on the M6 in the West Midlands: There is a signed diversion route available via the Hollow Triangle. Traffic should exit the M6 at J6 on to Salford Circus. Take the A5127 southbound then turn left on to the B4137 eastbound. Turn on to the A47 eastbound and then turn on to A452 southbound. Continue straight on to re-join the M6 at J5. We’ll bring you updates on this story as they become available. Want to keep up to date with the latest traffic and travel news?Each day Stoke-on-Trent Live journalists bring you the latest news on the roads and railways across Stoke-on-Trent, North Staffordshire, South Cheshire and further afield to help keep you on the move. For the very latest updates on roads including the M6, A500, A50 and more, visit our dedicated traffic and travel news channel here. We also run a live news feed each weekday, which you can access on our website’s homepage from 7am to 9pm from Monday to Friday. And for more as-we-get-it updates on the roads across the region and beyond, join The Sentinel’s traffic and travel Facebook group here.last_img read more

Plaintiff in sexual assault case against Costa Rica exlawmaker Justo Orozco rejects

Plaintiff in sexual assault case against Costa Rica exlawmaker Justo Orozco rejects

first_imgRelated posts:Costa Rica ex-lawmaker and anti-gay evangelical Justo Orozco arrested on alleged sexual abuse charges Costa Rican ex-lawmaker Justo Orozco faces another criminal complaint for alleged sexual abuse Prosecutors raid Costa Rica lawmaker Justo Orozco’s office in ongoing probe The happiness of Justo Orozco An attorney for the alleged victim in asexual assault case against former Costa Rican legislator Justo Orozco on Wednesday evening said his client had rejected a proposed out-of-court settlement. Attorney Santiago Arguedas said he would move forward with preparations for a criminal trial.“A legal case for a serious crime such as a sexual offense must be followed through to its final consequences,” Arguedas said at a press conference in his office in San José.Arguedas denied reports by several media outlets on Tuesday regarding a possible settlement in the case.“This case is not about flirting as the ex-lawmaker recently stated. It’s about criminal behavior, and that is what we told the court,” Araya said. “Orozco’s public statements in recent days are consistent with my client’s testimony, and he is admitting that the events occurred as described.”Arguedas said the alleged victim is stable and receiving psychological treatment that is recommended in cases of abuse.National Police officers on June 30 arrested Orozco, an outspoken anti-gay and evangelical former Costa Rican Renovation Party lawmaker, following the woman’s claims that he allegedly sexually attacked her inside a motel in Pavas, west of San José. The victim claims the two had met for a possible job interview, but ended up at the motel against the plaintiff’s will.The victim said at the time that Orozco then attempted to close the motel room’s garage door to trap her inside, but she managed to escape. According to her attorney, the plaintiff then ran to a nearby police precinct, where she reported the incident. Statements by police following the arrest said the alleged victim had flagged down a passing patrol car, but Arguedas clarified that his client had actually gone to a nearby police station.Orozco was arrested minutes later while driving near the motel and later released under preventive measures. The self-described moral crusader and outspoken advocate of “traditional family values” faces up to six years in prison if convicted of aggravated sexual assault, and three additional years if convicted of holding the alleged victim against her will.Orozco has told reporters he is innocent, and the entire incident was a big misunderstanding. His attorney told the daily La Nación that the alleged victim had actually harassed Orozco, phoning him several times to solicit a meeting.But the story doesn’t end there – a second plaintiff, a corrections officer at a large prison outside of Costa Rica’s capital, also came forward on July 1 and filed separate criminal sexual assault charges against Orozco for an incident that took place the same day as the alleged motel attack. Facebook Commentslast_img read more

Jim Rickards Secret Accounting Career In

first_img Jim Rickards’ Secret Accounting Career In 1977, before most of today’s Wall Street analysts were even born, Jim Rickards was doing complex tax and accounting work at Citibank. Now he has uncovered the biggest accounting hoax since Enron… one that could wipe out millions of Americans. Will you be a victim of this accounting scandal? Click here to find out. Recommended Links One of the world’s most important markets continues to flash danger signs… Regular readers know we keep close tabs on the bond market. The bond market is where individuals, companies, and governments go to borrow money. The U.S. bond market is about twice as large as the U.S. stock market. That’s one reason the bond market can signal trouble before the stock market. •  The junk bond market is where companies with shaky finances borrow money… Junk bonds are riskier than bonds issued by healthy companies, so they pay higher yields. When the economy slows, companies in bad financial shape often feel it first. That’s why economic trouble tends to show up in the junk bond market early on. •  Junks bonds are set to have their first down year since the financial crisis… On Monday, The Wall Street Journal reported that U.S. junk bonds are down 2% on the year. If they end the year down, it would be their first losing year since 2008. •  Bond defaults are at their highest level since 2009… Worldwide, companies have already defaulted on $95 billion in debt this year. That translates to 102 corporate defaults, or 42 more than last year. U.S. companies account for over half of these defaults. •  Moreover, the U.S. energy sector accounts for 26% of global defaults this year… Casey readers know the U.S. energy market is struggling… Yesterday, the price of oil hit a new six-year low. It’s plunged 66% since last June. And the price of natural gas has plunged 56% since last summer. Most oil and gas companies’ profits have plummeted. As a result, companies that borrowed big before energy prices crashed are struggling to pay back their loans. •  Credit rating agency Standard & Poor’s says half of all energy junk bonds are distressed… A distressed bond has a high risk of default. And the trouble isn’t isolated to energy bonds. Last week, Bloomberg Business reported that 20% of all U.S. junk bonds are now distressed. That’s the highest level since September 2009. •  Corporate defaults could double in 2016… So far, only 2.6% of junk bonds have defaulted this year. However, that figure will likely jump soon. On Monday, The Wall Street Journal reported that defaults are expected to nearly double to 4.6% next year. If that happens, junk bonds would pass their 30-year average default rate of 3.8%. That also hasn’t happened since 2009. •  Meanwhile, the U.S. stock market is showing big cracks… Last week, we explained how a handful of huge companies are making the U.S. stock market look healthier than it really is. This includes Google (GOOG), Microsoft (MSFT), Amazon (AMZN), Facebook (FB), and Netflix (NFLX). When most investors talk about “the stock market,” they’re talking about the popular S&P 500 index. The S&P 500 is weighted by company size, which means bigger companies affect its performance far more than smaller companies. For example, Google is the second-largest company in the S&P 500. It’s up 43% on the year. Amazon is the sixth-largest company. It’s up 113%. Facebook is the eighth-largest. It’s up 35%. Meanwhile, S&P 500 stocks are trading 18% below their 52-week highs, on average. •  This chart shows what’s really happening in the stock market… It’s one of the most important charts in the world right now… It compares the S&P 500 with a version of the S&P that gives equal weight to every company. In the equally weighted S&P, toymaker Hasbro (HAS) has as much weight as Google, which is 61 times bigger than Hasbro. Only way for Americans to legally pay close to ZERO taxes 70-year-old multimillionaire has revealed greatest – and least known – American tax “loophole.” Click here to get the full details. – •  The U.S. stock market flashed the same red flag in 1999… A handful of big stocks pulled the major indices higher that year, while most U.S. stocks struggled. By 2000, the S&P 500 turned down and went on to lose 48% in 32 months. The NASDAQ crashed 78% in the same time. The U.S. stock market is like a healthy-looking tree that’s actually rotting on the inside. Eventually, when the largest stocks can’t prop it up anymore, the entire tree is going to fall. •  We recommend investing with extreme caution right now… You should hold a significant amount of cash and some physical gold. You may also want to hedge your portfolio by shorting (betting against) stocks likely to crash hard during the next big downturn. This could mean shorting very expensive stocks. It could also mean shorting businesses that will struggle to make money during a prolonged economic slowdown. We recently recorded a video presentation on the topic of investing during difficult times. Doug Casey, founder of Casey Research, gave his advice on how to protect your money and make more money during a major market collapse. Click here to watch – it’s free. Chart of the Day Here’s another clue U.S. stocks are topping out… Professional investors often look at “spreads” to gauge the market’s strength. A spread is the difference between two prices or interest rates. One important spread subtracts the interest rate paid by junk bonds from the interest rate paid by U.S. Treasuries. U.S. Treasuries are bonds issued by the U.S. government, which is widely considered one of the safest borrowers in the world. Junk bonds, on the other hand, are issued by riskier borrowers. Today, the interest rate on Treasuries is 2.1% and the average interest rate on junk bonds is 8.8%. So the “spread” is 6.7%. When the economy is humming along, this spread typically gets smaller. Companies generally make good on their bonds during good economic times, so investors don’t demand a big interest rate premium. However, when the spread starts to get bigger, it’s a sign of trouble ahead for the stock market. For example, this spread started to get bigger in the summer of 2007. Smart investors knew this was a bad sign. They got out of the stock market and saved a ton of money. As you likely remember, the S&P 500 peaked in October 2007, and went on to crash 57%. For the first time in four years, this spread is getting significantly bigger. As you can see, the U.S. stock market and spread moved together while stocks were in a clear-cut bull market through mid-2014 (the spread is inverted on the chart below). Then, they diverged. The spread has more than doubled, while the S&P 500 remains near all-time highs. This is another reason to be very cautious in the stock market today. These two indices tracked each other for most of 2015. However, in recent weeks the S&P 500 has pulled ahead of the equally weighted S&P, which is now down 4% on the year. This is a big red flag. It’s confirmation that a few big companies are holding up the stock market. — Regards, Justin Spittler Delray Beach, Florida December 11, 2015 We want to hear from you. If you have a question or comment, please send it to feedback@caseyresearch.com. We read every email that comes in, and we’ll publish comments, questions, and answers that we think other readers will find useful.last_img read more

Just over four years ago on July 17 2014 six de

Just over four years ago on July 17 2014 six de

first_imgJust over four years ago, on July 17, 2014, six delegates on their way to the International AIDS Conference died in the shoot-down of Malaysia Airlines Flight 17 over eastern Ukraine.The delegates were among the 298 people killed hours after their flight took off from Amsterdam.International investigations concluded that the missile that downed the jet originated with the Russian military, which has denied involvement. This year, Amsterdam is where thousands of experts in public health and global development are gathering for the International AIDS Conference, which begins on Monday.”I’m hopeful that people will still remember them,” Owen Ryan, the outgoing executive director of the International AIDS Society, says of the colleagues he lost in the AIDS prevention research and activism community that day. Ryan told NPR’s Korva Coleman he wants their legacy to help draw attention to AIDS as a continuing crisis, “and know it’s important we keep this fight going.”About 37 million people around the world were living with HIV/AIDS in 2017, according to the World Health Organization. The group says 940,000 people died of HIV-related diseases last year. On the eve of the 22nd International AIDS Conference, Ryan talked with NPR about the current state of the AIDS crisis around the world and why it’s important to keep funding AIDS prevention efforts.Interview HighlightsOn Joep Lange, a former president of the International AIDS Society who died on MH17It’s hard to describe in short ways all the ways that Joep had kind of really transformed the HIV movement. One very large way though was how he made the world wake up to the need for antiretroviral treatment in Africa. He was one of the first researchers, scientists, activists who was forcing donor governments to face the problems that were in Africa — and to get rid of the impediments that were keeping people away from lifesaving treatment.He is in large part to thank for many of the millions of people who are on treatment today. On what can slow down the rate of current AIDS infectionsHonestly, what needs to be done is this sense of complacency that has settled on many of us. There’s really this feeling in many parts of the world that AIDS is over, and that is really far from true.It’s one of the reasons we miss Joep the most right now — he had an unbelievable ability to speak truth to power, regardless of who he’s speaking to. He just knew how to go right to them and say, “What you believe is not true and we need more money for this.”On the development of drugs to stop AIDSFor one of the first times, we’re doing a large-scale clinical trial for vaccines in South Africa. And South Africa’s one of those countries where if we can get it right there, we can get it right in a lot of places around the world. But until we get more people on treatment in the short term, we’re going to keep trying to play catch-up. So we’re really hoping we can do both things at the same time: get people on treatment, and then longer-term prevention options.On particular regions where the AIDS crisis is growingEastern Europe and Central Asia is a big focus of this conference. You’ve seen that over time as economies have improved, donors have walked away. And with them walking away has walked away political will. So in many places, and this also includes Russia, you’ve seen the epidemic come back with force. And you’re seeing in urban centers and rural areas people who are just completely away from treatment and this massive explosion in new infections and I think people just don’t realize it.On preventing future epidemicsWe always have to be aware and it’s the exact moment you take your finger off the pulse of epidemiology that you start to see problems occur. We need to fund the systems that keep us vigilant against the next great disease that’s coming — ’cause we know it’ll happen. We’ve seen this with Ebola, we’ve seen this with SARS in the past. We need to keep things like the CDC and WHO — we need to keep them vibrant and strong and paying attention to all of this. Copyright 2018 NPR. To see more, visit http://www.npr.org/.last_img read more

Winning in the Era of Deep Contextual Personalization Its All About HumanMachine

first_imgWinning in the Era of Deep Contextual Personalization: It’s All About Human-Machine Collaboration Sunil KarkeraApril 29, 2019, 4:00 pmApril 25, 2019 Chatbots, virtual assistants and other Artificial Intelligence (AI)-powered marketing technologies are rapidly becoming commonplace. Yet, many CMOs are discovering the limitations of these technologies for one-to-one marketing. How should CMOs be allocating their technology investments to deliver deep contextual personalization and create ever-expanding customer experiences that will fuel growth for the next decade?The answer to that question has been elusive. The truth is, most CMOs are bewildered by the vast and ever-increasing array of marketing technologies available. In 2018 alone, marketers were inundated with nearly 7,000 software products from more than 6,000 companies, according to Scott Brinker of HubSpot. In many cases, the scars of integration are still fresh — as are memories of tech investments that didn’t deliver the anticipated results. So, it’s not surprising many CMOs have worked to greatly simplify their marketing stack.New Pressures Demand a New ApproachBut relying on existing personalization strategies is no longer enough. Pressure continues to grow for CMOs to demonstrate ROI. After three straight years of increases in marketing spend industry-wide, budgets have slipped from a peak of 14% of revenue to 11%. Forward-looking marketing leaders know they need new approaches to enhance customer experience, improve channel effectiveness, and use data more effectively to improve marketing agility and fuel marketing innovation. What they need is a holistic approach that balances human and machine intelligence. The question is: What is the right balance in this human-machine collaboration?I believe the key to success is a “machine-first” approach where technology has the first right to sense, understand, decide, and act. This means automating a vast number of activities that are still performed manually. A machine-first approach is about augmenting human capability using automation and AI to increase the growth potential of the enterprise. It enables monitoring customer engagement before and after the sale, automatically adjusting campaigns and engagements—from media selection and channels to messages and segmentation—on the fly to create a deep contextual experience that engages customers and inspires loyalty.Currently, most marketing organizations are only scratching the surface, using digital technologies to personalize the brand experience in limited ways—generally at the point of transaction. A true machine-first model is about managing and personalizing the brand experience throughout the customer lifecycle in an end-to-end role that extends beyond marketing into sales, service and support, and even product/service design and development. The goal of machine-first is not only to streamline processes but also to master digital data—capturing and analyzing the precise customer data needed to inform the actions and decisions of human marketing teams.Read More: Making Voice Tech More Human Is as Easy as 1-2-3Machine-First Enables the Optimal BalanceSo, what does a machine-first model look like in practice and how does this help achieve the right balance in human-machine collaboration?To create stickier relationships with its customers, Starbucks created the Starbucks Rewards program to support true one-to-one marketing. In one year, the program added more than 10 million members in the US. A comprehensive cross-channel program, Starbucks Rewards gathers and analyzes customer data across all touchpoints to build a granular consumer profile—then automates the delivery of personalized offers to each individual consumer. This reinforces the bond between Starbucks and each customer, encouraging consumers to engage with the brand on their terms, using whatever platform they want at any given time. Starbucks’ use of omnichannel data to build loyalty enables the human component as well—the in-store experience—where store managers and staff focus on customers as individuals, not just as orders. This “people-centricity”—always core to Starbucks’ culture—is strengthened, not diminished or replaced, by the company’s automated, data-informed loyalty strategy.Deep personalization is also crucial after the sale. Fiat Chrysler Automobiles (FCA) Brazil recognized that post-sales service of vehicles is a make-or-break factor for customer satisfaction and brand loyalty. To ensure a seamless customer experience across all service touchpoints, FCA integrated key functions across its customer interaction channels. This enabled proactive, personalized communications at every step through automated processes focused on a single goal: rapidly understanding and resolving the customer’s need or problem. AI-powered business intelligence provided human service agents with the customer insights needed to answer questions and solve issues quickly and effectively. This ideal balance of machine and human intelligence helped FCA Brazil accelerate complaint resolution by 25%. Based on this result, FCA is rolling out their human-to-machine service model worldwide.Reshaping Customer ExperiencesDeploying a balanced human-to-machine strategy requires CMOs to break free from a reactive, tactical mindset and view the entire customer lifecycle—from initial prospecting, nurturing and engagement to ongoing loyalty and support efforts, and even win-back campaigns—as a single, seamless, one-to-one conversation with each customer. Digital intelligence makes this possible by automating and orchestrating processes, and by creating linkages across channels and data sources to create a seamless, personalized experience.The supply chains for Global 2000 companies have been doing a version of this for years. They leverage digital technologies to detect demand signals out to the point of sale, enabling proactive adjustments in production, inventory, and distribution to keep pace with changes in consumer behavior. Marketers must do the same, using every customer interaction to generate signals that automate actions and enhance the consumer profile, enabling marketing and service organizations to anticipate and fulfill customer needs and desires, moment by moment.Read More: How Managed Execution Services Help Marketers Yield Better ResultsThe People Part of the EquationThis transformation is equally about people. CMOs need to identify, staff and train people for the new marketing roles that are becoming essential to operating a world-class, machine-first marketing organization. In particular, CMOs should rethink their talent strategy. For example, marketers need to be trained on data and analysis. CMOs are now bringing data scientists to their teams as a different set of talent is required for the marketing future.These professionals must master digital data to be “data-informed” rather than “data-driven.” This means determining what customer data they need and what they don’t need to deliver ROI. They must continually seek new ways to use that data to deliver value to customers, while respecting and protecting customer privacy. And, they must be able to think outside their marketing silo, tearing down the old walls that separate corporate functions and create new ways to improve every customer interaction, both pre- and post-sale.Breaking Through the BarrierAdopting a model that properly balances the capabilities of skilled humans and those of intelligent machines is the key to breaking through the technology plateau that is holding back many marketing organizations. It’s the only way to deliver the deep personalized experiences consumers demand—and the technology ROI that CFOs demand.Read More: 7 “Gotchas” for Data Engineers New to Google BigQuery AIchatbotsDeep Contextual PersonalizationhubspotHuman-Machine CollaborationROIScott BrinkerTCS Interactive Previous ArticleMarTech Interview with Jeremy Korst, President, GBH InsightsNext ArticleWhat Kind of Chatbot is Right for Your Business?last_img read more

Circulating tumor DNA can help detect treatment options for ovarian cancer subtype

first_imgReviewed by James Ives, M.Psych. (Editor)May 6 2019According to a new research, circulating tumor DNA can be used detect treatment options for ovarian cancer patients who don’t benefit from chemotherapy.High-grade serous ovarian cancer (HGSOC) is the most common and aggressive subtype of ovarian cancer. The HGSOC tumors consist of several heterogeneous cell populations with a large number of mutations. This genetic variability makes it difficult to find drugs that would kill all the cancer cells, and to which the cells would not become resistant during treatment.Over half of the patients diagnosed with high-grade serous ovarian cancer die within five years of diagnosis, that is, annually more than 150000 women globally. To improve the efficacy of HGSOC treatment, a research group from University of Helsinki, together with researchers from University of Turku and Turku University Hospital, have now studied the use of circulating tumor DNA in finding precision medicine-based treatments for the disease.Circulating tumor DNA refers to tumor-derived cell-free DNA in the bloodstream. Circulating tumor DNA detection is a minimally invasive technique that offers dynamic “molecular snapshots” of genomic alterations in cancer.”Analyzing circulating tumor DNA enables us to detect genomic alterations also in late stage cancers in which taking biopsies from the tumor is difficult or even impossible. In the current research, we demonstrated that circulating tumor DNA can be used to monitor the patient responses to treatment, and find drug combinations to target the Achilles’ heels of the tumor’s genomic profile,” says Professor Sampsa Hautaniemi, director of the Systems Oncology Research Program in the Faculty of Medicine at University of Helsinki.Related StoriesSpecial blood test may predict relapse risk for breast cancer patientsBacteria in the birth canal linked to lower risk of ovarian cancerUsing machine learning algorithm to accurately diagnose breast cancerThe results were published in JCO Precision Oncology.Hautaniemi’s research group has implemented a clinical circulating tumor DNA workflow to detect clinically actionable alterations in more than 500 cancer-related genes.In the present study, the researchers analyzed 78 circulating tumor DNA samples from 12 ovarian cancer patients before, during and after the treatment using bioinformatics analysis, and in-house Translational Oncology Knowledgebase to detect clinically actionable genomic alterations.DNA alterations associated with clinically available drugs were detected in 58% of the patients. The treatment of one patient has already been tailored successfully based on the results. For the other patients the results may be useful if their cancer relapses.The results demonstrate a proof-of-concept for using circulating tumor DNA to guide clinical decisions. Furthermore, the results show that longitudinal circulating tumor DNA samples can be used to identify poor-responding patients after first cycles of chemotherapy.In addition, the researchers provide the first comprehensive, open-source circulating tumor DNA workflow for detecting clinically actionable alterations in solid cancers.”The prognosis of ovarian cancer patients is still poor. However, the future looks brighter as research has discovered targeted therapies for the genomic alterations also in ovarian cancer tumors. We are currently in the forefront of the precision medicine for ovarian cancer. Our goal is to find out how ovarian cancer becomes resistant to current treatments, and use this knowledge in finding more effective precision treatments,” Hautaniemi says. Sources:The University of Helsinki.Journal reference:Jaana Oikkonen et al. (2019) Prospective longitudinal ctDNA workflow reveals clinically actionable alterations in ovarian cancer. JCO Precision Oncology. doi.org/10.1200/PO.18.00343.last_img read more

Research on cannabis use in women limited finds new study

first_imgImage Credit: OpenRangeStock / Shutterstock In 2016, over 190 million people in the world used cannabis, making it the third most commonly used drug in the world. Cannabis use is linked to certain risks, most notably that of psychosis.Cannabis psychosis has a tremendous negative impact on both cannabis users and their families. The relationship between cannabis and psychosis has been a bone of contention for a long time among addiction researchers. An accurate understanding of this would help greatly to direct limited health resources towards those at highest risk.While this association has been known for more than a hundred years, increasing cannabis use in the Western world brought it to the attention of researchers. Andreasson et al. performed a foundational study (in male users) which set the direction for research in this area for decades. They concluded that cannabis independently increased the risk of developing schizophrenia, to 6% of heavy users.Researchers have not yet been able to determine at what point cannabis-induced psychosis may be diagnosed. Both acute and long-term psychotic reactions occur, which means the statistics vary with place, assessor, and type of evaluation.Scientists currently favor one of three explanations for the link between cannabis use and schizophrenia. One, cannabis use triggers schizophrenia in some individuals. This is difficult to prove, because cannabis metabolites continue to be excreted in urine for weeks following a single use, which enormously increases the chances of a false diagnosis of cannabis psychosis.Two, schizophrenics use cannabis to treat their early symptoms. This, however, belies the most common reasons given by the users themselves to explain why they use the drug, namely, pleasure and recreation.Certain cannabidiols are useful in treating schizophrenia, adding plausibility to the theory. Against this we must set the fact that in recent times the concentration of the potent and pro-psychosis compound Δ9-tetrahydrocannabinol (THC) has risen, relative to the less potent cannabidiols (CBD) in cannabis.Related StoriesAMSBIO offers new, best-in-class CAR-T cell range for research and immunotherapyAXT enhances cellular research product portfolio with solutions from StemBioSysSchwann cells capable of generating protective myelin over nerves finds researchFinally, there are factors which predispose to both schizophrenia and to cannabis use.Ian Hamilton, the author of the current study, observes that cannabis is being legalized in many countries worldwide, for medical and recreational use. Yet, at the same time, we are possibly missing important information on the topic because of inadequate research.Most research has concentrated on teasing out genetic and biologic risk factors for cannabis psychosis. This means that we have largely neglected the impact of social and cultural factors which may be just as important.  In the current study, which carried on past work from the same institution, two issues came to the fore.The first was an obvious lack of female representation in cannabis research. Women cannabis users are simply not present in the vast majority of cannabis studies. Hamilton cites a possible link to the lack of women scientists in the field of addiction research.The second issue relates to the focus of addiction studies in the developed world. Most researchers in this field have focused on America, Europe and Australia, leaving out vast and populous areas like Africa, Asia and the Middle East.Studying cannabis use and effects in other cultures and regions could help us understand the risk factors for cannabis psychosis much better. For instance, is the low incidence of psychosis in some regions of Asia linked to the smaller population of cannabis users there?Again, is tobacco synergistic with cannabis in increasing the psychosis risk? Knowing this could enable us to focus on helping cannabis users quit tobacco to reduce this risk.The study concludes that we need much more research to elucidate the risk factors for cannabis psychosis. This should include many more women cannabis users as well as other geographical areas of the world.Hamilton says, “We need to accept that cannabis psychosis is about more than genetics or biology but is effected by social factors such as where and how young people grow up and the problems they experience as they develop.” The increasing legal access to cannabis in America “presents a large naturalistic experiment”, he says, which will provide data in a few years on how cannabis affects health and psychosis trends in the population. By Dr. Liji Thomas, MDJun 5 2019A new study from the University of York shows that research into the association of psychosis with cannabis focuses almost completely on men users, significantly limiting our knowledge of the drug’s effects on human health.center_img Source: Hamilton, I. and Monaghan, M. (2019). Cannabis and Psychosis: Are We any Closer to Understanding the Relationship? Current Psychiatry Reports. https://link.springer.com/article/10.1007%2Fs11920-019-1044-xlast_img read more

Craigslist ends personal ads after US sex trafficking bill passes

Ivanka Trump, daughter of US President Donald Trump, hosted a White House meeting on sex trafficking on March 13; she is seated between Senators Rob Portman and Amy Klobuchar Explore further The move by Craigslist suggested that websites may shutter or censor some content to avoid prosecution under the Stop Enabling Sex Traffickers Act (SESTA) approved by Congress this week and awaiting President Donald Trump’s signature. Craigslist said in a statement it ended personals over concerns the law could subject websites to criminal and civil liability for third-party content.”Any tool or service can be misused,” the statement said.”We can’t take such risk without jeopardizing all our other services, so we are regretfully taking craigslist personals offline. Hopefully we can bring them back some day.”Lawmakers contended websites such as Backpage facilitated sexual exploitation including prostitution and human trafficking through their adult services listings. Craigslist ended adult services ads in 2010.Critics of the legislation argued that it undermine a basic underpinning of the internet, which enables websites to host information from third parties without liability.The measure “creates a host of obstacles to the free and open internet,” said Emma Llanso of the Center for Democracy and Technology, a digital rights organizations.Robyn Greene of the New America Foundation’s Open Technology Institute said the law “will result in increased censorship and harm the internet economy, hitting small businesses and start-ups the hardest, but it won’t effectively combat human trafficking.”Greene added that the measure “could even do real harm by driving the perpetrators of these horrible crimes further underground.”The White House has endorsed the bill, and Trump’s daughter Ivanka hosted a meeting earlier this month with sponsors of the legislation, saying it was needed to help crack down on human trafficking using the internet. Citation: Craigslist ends personal ads after US sex trafficking bill passes (2018, March 23) retrieved 18 July 2019 from https://phys.org/news/2018-03-craigslist-personal-ads-sex-trafficking.html Craigslist said Friday it shut down its personal ads section as concerns grew over unintended consequences of a law approved by Congress which could hold websites liable for promoting sex trafficking. This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. © 2018 AFP Tech sector battles US lawmakers on sex trafficking bill read more