Christian Pulisic reveals why he joined Chelsea

Christian Pulisic reveals why he joined Chelsea

first_imgBorussia Dortmund winger Christian Pulisic insists the reason why he joined Chelsea is because of their style of play under Maurizio Sarri.The Blues completed the signing of Pulisic early last week for a fee in the region of £58million but the youngster will spend the remainder of the season with Dortmund.The United States international was one of the most sought-after youngsters in the game following his impressive string of performances since appearing in the first team of the Black & Yellow in 2016.The 20-year-old’s current contract at the Signal Iduna Park was due to run out at the end of the 2019-20 campaign, but after only starting 11 games this season, the club hierarchy decided to sell him.Jadon SanchoMerson believes Arsenal should sign Sancho Manuel R. Medina – September 14, 2019 Borussia Dortmund winger Jadon Sancho might be the perfect player to play for the Gunners, according to former England international Paul Merson.Speaking about his reason for moving to Stamford Bridge, Pulisic said, according to talkSPORT: “I’ve seen their style of play.”“I’ve always appreciated how they’ve played football, and it’s really nice how they play now, with their new coach. It fits me very well.”last_img read more

Youngster Kyle Taylor is earning a lot or praise

Youngster Kyle Taylor is earning a lot or praise

first_imgThe AFC Bournemouth footballer has signed a three-and-a-half year contract after he impressed everybody when playing for the team’s senior squad.19-year-old Kyle Taylor is a product of AFC Bournemouth Academy.The youngster was spotted by academy manager Joe Roach.And now the midfielder has been called to the first team and has signed a new three-and-a-half year contract with the English Premier League club.“Kyle has been with us for the whole length of the journey and it’s great to see,” Roach told the team’s official website.“He was fairly slight when he was younger but he has always been very technical and a nice player who caught the eye.”Brad Smith is loving his time at MLS Manuel R. Medina – August 27, 2019 Smith has been loaned from AFC Bournemouth to Seattle Sounders for a whole season, and the Australian footballer is enjoying his time there.“He was given an early scholarship, which is not the norm, and played up a year and did well,” he explained.“Like with all young players, there were areas of his game he needed to improve.”“When Carl Fletcher and I came back to the club in 2014, Kyle was at the start of his scholarship journey,” he added.“We viewed him in terms of how we were going to fit him in with regard to his physical side and perhaps trying to be a little stronger mentally.”“We spoke to Kyle and his parents and outlined what we felt he needed to do to make sure he got over the line at the end of the scholarship. It was quite strong but it centered on what he needed to focus on,” Roach continued.“His response was fantastic. It was one of those moments I remember, as I have with others when one little seed made sure he focused on where he should be.”last_img read more

Be Advised Of Hazardous Driving Conditions

Be Advised Of Hazardous Driving Conditions

first_imgThe City of Soldotna released a statement, driving conditions are very hazardous right now. City sanding trucks are out, and we want to encourage everyone to drive very carefully, or stay home if don’t have to be out on the roads. Plan ahead for icy driving/difficult driving conditions if you are heading to Anchorage from the Kenai Peninsula within the next 24 hours. Travel still not advised by the Department of Transportation on the Seward Highway due to the recent landslide danger. Drivers should expect wet and icy roads, icy patches, ice glaze, ice, black ice, slippery road surface, reduce your speed, ice on bridges/overpasses.center_img Facebook0TwitterEmailPrintFriendly分享The recent rainfall and freezing temperatures have caused very difficult driving conditions in the Kenai Peninsula area.last_img read more

WHS VOLLEYBALL Wildcats Win 5 InARow Get Back To 500

WHS VOLLEYBALL Wildcats Win 5 InARow Get Back To 500

first_imgGoing into this match, we were warned that Watertown had a very scrappy defense, but not a very potent offense. We stressed to the girls how important it was for them to keep the ball in play against a scrappy team. Keep our errors to a minimum and look for our opportunities to score.The Wildcats came out strong in the first set. Watertown ran very few attacks, relying instead on just keeping the ball in play with free balls trying to score on 2nd ball over. Wilmington stayed patient and kept the ball in play, running their own attacks and scoring when they could. Once again, after a dominant first set, there was some let-down in the second set. To their credit Watertown did a much better job of running an offense and managed to score more often, but Wilmington held tough and gutted out a narrow victory. We made a small change to the lineup in the third set to let Raegan Sweeney play all the way around again, and have her use her powerful swings to generate some energy. She did a great job, sparking the team to a dominant third set victory.Serving was a strength again this set with 96% serving, 10 aces and only 3 errors. Six of our nine active players served 100%! Our lowest serving percentage was 75%. It was great to see the girls putting our instructions into practice and not giving points away.Our game plan in this match was to attack Watertown out of the middle. Both Gianna Brunetto and Maeve Cadogan rose to the challenge. Gianna continues to thrive in the middle with 7 kills and only one error. Maeve contributed another 6 kills and only one error. Gabby Bond had 7 kills from the outside.Coming UpThe match against Watertown marked the mid-point in our 2018 season. Wilmington now stands at 3-5 in the Middlesex League and 5-5 overall. The season continues with a match against perennial powerhouse Winchester (6-2) at home on Tuesday, Oct 2nd at 4:00 pm, and away at Arlington (0-5) on Thursday, Oct 4th at 4:00 pm.Dig PinkWe seeking community support for our annual “Dig Pink” fundraiser in support of the Sideout Foundation and the work they do to support Stage 4 Breast Cancer patients and their families as the fight this terrible disease that continues to afflict so many in our community and in our families.This season, our Dig Pink fundraiser will be taking place on Friday, October 12th, during our match against Melrose. The JV and Freshman teams will be taking the court at 6:00 pm, followed by the Varsity match at 7:00 pm.We will be selling baked goods, as well as raffling off gift baskets between matches as well as between sets of the varsity match. All proceeds for the evening will go directly to the Sideout Foundation.We appreciate your support, and we look forward to seeing you in the gym.Like Wilmington Apple on Facebook. Follow Wilmington Apple on Twitter. Follow Wilmington Apple on Instagram. Subscribe to Wilmington Apple’s daily email newsletter HERE. Got a comment, question, photo, press release, or news tip? Email wilmingtonapple@gmail.com.Share this:TwitterFacebookLike this:Like Loading… RelatedWHS VOLLEYBALL: Wildcats Go 2-1 For The Week With Wins Over Triton & WakefieldIn “Sports”WHS VOLLEYBALL: Wildcats Fall To Reading & Melrose In Close MatchesIn “Sports”WHS VOLLEYBALL: Wildcats Have Best Week Of The Season (So Far)In “Sports” Newburyport115251917 Watertown012239 Wilmington3252525 On Tuesday, we travelled to Stoneham to take on the Spartans. Coming off a few recent victories the girls seemed ready to turn it on against Stoneham. I continued to stress the need to play smart. Serve in! Hit in!Apparently Brittany Cimaglia took my instructions to heart. After we got our first point on a great play from serve receive, Britt went on a run of 14 straight serves to stake us to a 15-0 lead. Wilmington never looked back in that set, allowing Stoneham only six more points in that set. As is often the case after a blow-out victory, there was a let-down in intensity and focus on our part, leading to a 4-8 deficit early on. But they were able to pull it together, tie it up and extend out to a 22-10 lead, before closing out the second set 25-14. The third set was closer, but Wilmington held the lead from start to finish.This was the Wildcats best serving performance of the season, serving 93% with 17 aces and only 5 errors! As mentioned earlier, Britt Cimaglia was outstanding, serving 97% with 10 aces and only 1 error on 33 service attempts. Anna Rideout and Khrystyna Fedynyak contributed perfect serving outings as well.We saw great improvement in our offense during this match as well, with a total of 22 kills and only 12 errors during the match. Our new middle hitter, Gianna Brunetto had a great night with 8 kills and only one error. Gabby Bond also contributed 8 kills with only one error. Maeve Cadogan had 5 kills with only one error.We were very pleased with the way that the team played their game during this match, no matter whether Stoneham was running an offense at them or just dumping free balls at them. They maintained their composure and got their jobs done.Watertown Wilmington325232525center_img Newburyport continues to improve, and is proving to be a competitive adversary. We have been trying to stress to the team how important it is to play smart: serve aggressive, but serve smart; hit aggressively, but hit in.. Don’t just try to overpower our opponents, but keep them out of system to get more opportunities to run an offense. Hit the ball over the net and find the court. We have a few really tough servers who were able to do exactly what we were looking for.In the first set, we got out to a lead and were able to maintain it all the way to the end. The second set started out the same, but Newburyport was able to stay close and finally close out a tight set, 25-23. In the third set, the team got out to an early lead again. Newburyport came close, but this time, Wilmington was able to hold on for the win. In the fourth set, Wilmington came out strong opened a wider lead and was able to close out the match.Overall we served 88% with 25 aces and only 11 errors. Maeve Cadogan led the team with 100% serving and three aces. Britt Cimaglia and Gabby Bond once again were strong servers for us with 96% serving and 8 aces and 5 aces respectively with only a single error each.We were not as pleased with our offense, which got 20 kills in the match, but also made 19 attack errors. Again, we need to play smarter in order to continue to be successful. Gabby Bond led the team with 6 kills, and Raegan Sweeney contributed 5 kills.Injuries are bound to happen during the course of a season, and we lost one of our Middle Hitters during the first set of this match. We tried a couple of different players at middle, and finally decided on playing Gianna Brunetto at middle. This decision worked out well in the Newburyport match and the remaining matches this week.Stoneham Wilmington3252525 Stoneham071419 WILMINGTON, MA — Below is the latest weekly recap from WHS Volleyball Coach Bruce Shainwald.Newburyportlast_img read more

Arm chip designs will speed up 2020 Android phones

first_img May 30 • Alienware redesigns its thin gaming laptops and offers OLED May 29 • The laptops of tomorrow will make us even more productive — and it’s terrifying Share your voice Tags May 29 • The outrageous computer cases of Computex 2019 See All May 30 • Computex 2019: Every announcement you need to know Computex 2019 •center_img Rene Haas, head of Arm’s intellectual property group, speaking in 2018 Stephen Shankland/CNET For a preview of the top-shelf Android phones that’ll arrive in 2020, check out the Arm Cortex-A77 processor design — and the 20% speed boost it should bring to smartphone chips.UK-based Arm designs chips and licenses those designs to companies like Samsung, Qualcomm and MediaTek. Some companies, like Apple, license only the chip instruction set,  the interface that software uses to command a chip. Others license complete CPU designs, like the A77. Licensees combine those chip brains with other components, like Arm’s new Mali-G77 graphics processing unit, into a single package called a system on a chip.The A77’s performance boost over today’s chips, known as A76s, requires more power out of your phone’s battery, says Rene Haas, president of Arm’s intellectual property licensing group. Arm announced the new chip technology at the Computex show in Taiwan, along with plans by MediaTek to use it in chips coming early in 2020.Better performance is important for getting more out of our phones. We’re holding onto our phones longer, but when we do upgrade, speed lets us tap into new features, like useful speech-to-text transcription, video editing and gender-swapping Snapchat filters.What remains to be seen is whether Arm’s A77 will help Android phones close the performance gap with Apple’s iPhones. Apple’s iPhone XS scores 4,797 on the Geekbench speed test using Apple’s own processors, compared with 3,414 for the Samsung Galaxy S10 using Qualcomm’s Snapdragon 855 chip — the phone version Samsung sells in the US.Different chipmakers can choose to boost performance with features such as better graphics, dedicated circuitry for AI and larger amounts of cache memory for high-speed data access. All that makes chips bigger and more expensive, though, so chipmakers make different decisions about the best choices for their products.Arm also says its G77 graphics processing unit design is 40 percent faster than the current G76. That’s chiefly useful for gaming, where players can get fancier imagery or smoother motion, but also for higher resolution displays that have to churn through more pixel data.”The game will never stutter,” Haas said. And the extra performance is also good for the larger displays of folding phones, like Samsung’s Galaxy Fold.Though the A77 brain doesn’t come with dedicated circuitry for AI work the way higher-end processors from Apple and some others do, Arm offers an AI option through its Project Trillium designs. And even without that, lots of software uses the plain old CPU for AI. Arm’s optimization work gives a significant boost to AI software frameworks like Google TensorFlow, Haas said.Lots of mobile chipmakers employ other AI chip designs, but Haas thinks they’ll come into the Arm fold. “Unless it’s quite a bit higher performance, you have to ask yourself why you should build this when you can get it from Arm,” he said. 3 Comments Computex 2019 reading • Android phones due for 20% speed bump in 2020 with new Arm chip tech Mobile Qualcomm Processors ARM Samsung Applelast_img read more

William Tech is everything especially music

first_imgBlack Eyed Peas frontman Will.i.am believes tech and music are one and the same.  Rick Kern/Getty Images Will.i.am is perhaps best known as a musician and lead member of the Black Eyed Peas, but he’s also working to make a name for himself in tech. The singer, songwriter and producer has dabbled in wearables with products like the Puls smartband and the i.am+ Dial smartwatch, and in 2015 teamed up with Gucci to create a luxury phone-free smart band, which never materialized. He’s also launched products like a triangular backpack with speakers and a Foto.sosho iPhone case, and is the founder of i.am+, an AI-centered tech company.  Now, Will.i.am is looking toward the future — one he believes will be shaped by tech like augmented and virtual reality. Devices like glasses will augment our world and free up our hands, he says, and technology will be more seamless. He imagines that musicians 100 years from now will have to do more than just write and perform songs. They’ll make VR experiences that audiences can virtually transport to.  The future of entertainment is VR and AR.  Will.i.am Will.i.am was pensive and enthusiastic about the future of tech when I spoke to him recently at Accenture’s innovation hub at Salesforce Tower in San Francisco. “The future of entertainment is VR and AR,” he said. “You’re creating worlds in VR and enriching environments with AR. I can’t wait for that to be the norm in our entertainment industry.”Ten years from now, he predicts, we won’t be staring at screens. Instead, sleek devices will show content right in front of our faces, eliminating the need for bulky gear resembling a helmet. That’s not to say Will.i.am is looking to create those products himself. His current passion is in artificial intelligence and natural language. His company i.am+ is focused on getting its AI system to be more efficient so that when people talk to a voice assistant, their search takes on a more conversational tone.  Will.i.am doesn’t see his passion for music and tech as disparate. In fact, if more people knew how creative tech really is, more kids would want to be scientists and engineers, he says. “It’s the most creative industry in society today,” he told me. “Tech is everything. Music is tech. Our industry was founded on technology. If we saw music and tech as the same and not separate, we wouldn’t have this gap of [tech] jobs that are unfilled.” Now playing: Watch this: 0 4:54 Share your voicecenter_img Post a comment Microsoft HoloLens 2: A first dive into the future of… Tags Music Tech Industrylast_img read more

25000 trees at Maheshkhali reserved forest may be cut down

25000 trees at Maheshkhali reserved forest may be cut down

first_img.The government has approved a project for setting up a oil terminal on 192 acres of land of a reserved forest in Maheskhali, defying objections from the forest department and environmentalists.If this project is implemented, some 25,000 trees will be cut down, the department has expressed apprehensions.”The construction work (as part of project impelentation) will cause soil erosion, water pollution, release of chemical wastes and a variety of natural disasters,” the forest department said in a letter sent to the environment and forest ministry last year.The ministry sent a proposal to the cabinet division on 27 March, seeking permission for felling thousands of trees at Maheshkhali reserved forest to construct the oil terminal.The government gave Bangladesh Petroleum Corporation (BPC) the permission on 1 March for construction of an unrefined fuel terminal, Maheshkhali in Cox’s Bazar, the country’s only hilly island. It will cost around Tk 45 billion.Environmental experts said implementation of such a project would result in damage to the forest and wildlife in Maheshkhali as well as a natural disaster.A fuel terminal, if set up, will affect biodiversity and ecosystem of Maheshkhali reserved forest, a home to endangered species such as Maya deer and python. Water in surrounding areas will be contaminated, the environmentalists pointed out.The environment and forest ministry said, a total of 1,701 old trees and another 1,250 trees of different types will be cut down for implementing the project. For the loss of forest resources, the BPC is set to pay Tk 13.6 million as compensation.The forest department initially estimated the value of overall loss at Tk 2.77 billion, but later refixed it downwardly — at Tk 470 million.Unrefined fuels, imported from abroad, will be brought to the Maheshkhali terminal directly from mother vessels in deep sea. The fuels will then be taken to Eastern Refinery in Anwara, Chattogram.The forest ministry’s acting secretary Abdullah Al Mohsin Chowdhury told Prothom Alo recently that such project has to be allowed for the sake of development.“We will, however, try to minimise the damage,” he said.The official added that the ministry has asked the BPC to plant saplings five times higher than the number of trees to be cut down, and nurture them for the subsequent 10 years.The ministry has already received the prime minister’s nod in favour of these activities, he claimed.The BPC had in 2016 sought the permission to acquire 192 acres of lands on the basis of lease from the forest ministry.A six-member expert committee was also formed to assess the value of biodiversity.A member of the committee and also professor at Chattogram University’s forestry and rnvironmental science department Kamal Hossain told Prothom Alo that they recommended not giving permission for using the forest land.”We attend meetings and seminars and make commitments to protecting forests. Returning home, we forget and give permissions to use forests. Such decisions will cause disasters in the coastal areas,” he expressed his views.Nature and wildlife expert Anisuzzaman, who is working for big government and UN projects, observed that forests and hills can easily be destroyed only after getting permission from the ministries.He said reserved forests have been the targets for implementing big projects and making infrastructures.*This report, originally published in Prothom Alo print edition, has been rewritten in English by Rabiul Islam and Farjana Liakat.last_img read more

M6 closed due to serious accident in West Midlands

first_imgGet the biggest Daily stories by emailSubscribeSee our privacy noticeThank you for subscribingSee our privacy noticeCould not subscribe, try again laterInvalid EmailThe M6 motorway is closed in the West Midlands following a ‘serious collision’ this evening. The accident has shut the southbound carriageway between J6 and J5 – with delays building. Three vehicles are believed to be involved, two lorries and a car, following the collision near Birmingham. Police and emergency services are at the scene as of 8.20pm on Thursday May 31 – and the motorway remains closed as of 11pm. A Highways England spokesman said: “The M6 in the West Midlands is currently closed between J6 and J5 while we assist Central Motorway Police Group and emergency services with a serious collision.” Traffic is currently queuing in the area, with reports of congestion stretching back to junction 7. Traffic England is currently suggesting motorists could consider the M6 Toll Road – and Highways England have now put a diversion in place (see below). We have no information yet on whether anyone has been injured. Trapped traffic is, as of 9.20pm, currently being released past the scene in lane one. A Highways England spokesman said: “Please be aware there is a lot of traffic to get through and we are going as quickly and safely as possible but this may take some time before you start to move.” The motorway is currently set to remain closed for several hours – with Traffic England currently estimating around midnight. In other traffic news nationally tonight, there is flooding on the A49 near Ludlow in Shropshire as heavy rain continues to batter the region. The M50 in Gloucestershire is also closed in both directions due to flooding. Read MoreYellow Weather Warnings for rain in force for Stoke-on-Trent until Friday night DIVERSION IN PLACE: Highways England have confirmed there is now a diversion in place following the collision on the M6 in the West Midlands: There is a signed diversion route available via the Hollow Triangle. Traffic should exit the M6 at J6 on to Salford Circus. Take the A5127 southbound then turn left on to the B4137 eastbound. Turn on to the A47 eastbound and then turn on to A452 southbound. Continue straight on to re-join the M6 at J5. We’ll bring you updates on this story as they become available. Want to keep up to date with the latest traffic and travel news?Each day Stoke-on-Trent Live journalists bring you the latest news on the roads and railways across Stoke-on-Trent, North Staffordshire, South Cheshire and further afield to help keep you on the move. For the very latest updates on roads including the M6, A500, A50 and more, visit our dedicated traffic and travel news channel here. We also run a live news feed each weekday, which you can access on our website’s homepage from 7am to 9pm from Monday to Friday. And for more as-we-get-it updates on the roads across the region and beyond, join The Sentinel’s traffic and travel Facebook group here.last_img read more

Jim Rickards Secret Accounting Career In

first_img Jim Rickards’ Secret Accounting Career In 1977, before most of today’s Wall Street analysts were even born, Jim Rickards was doing complex tax and accounting work at Citibank. Now he has uncovered the biggest accounting hoax since Enron… one that could wipe out millions of Americans. Will you be a victim of this accounting scandal? Click here to find out. Recommended Links One of the world’s most important markets continues to flash danger signs… Regular readers know we keep close tabs on the bond market. The bond market is where individuals, companies, and governments go to borrow money. The U.S. bond market is about twice as large as the U.S. stock market. That’s one reason the bond market can signal trouble before the stock market. •  The junk bond market is where companies with shaky finances borrow money… Junk bonds are riskier than bonds issued by healthy companies, so they pay higher yields. When the economy slows, companies in bad financial shape often feel it first. That’s why economic trouble tends to show up in the junk bond market early on. •  Junks bonds are set to have their first down year since the financial crisis… On Monday, The Wall Street Journal reported that U.S. junk bonds are down 2% on the year. If they end the year down, it would be their first losing year since 2008. •  Bond defaults are at their highest level since 2009… Worldwide, companies have already defaulted on $95 billion in debt this year. That translates to 102 corporate defaults, or 42 more than last year. U.S. companies account for over half of these defaults. •  Moreover, the U.S. energy sector accounts for 26% of global defaults this year… Casey readers know the U.S. energy market is struggling… Yesterday, the price of oil hit a new six-year low. It’s plunged 66% since last June. And the price of natural gas has plunged 56% since last summer. Most oil and gas companies’ profits have plummeted. As a result, companies that borrowed big before energy prices crashed are struggling to pay back their loans. •  Credit rating agency Standard & Poor’s says half of all energy junk bonds are distressed… A distressed bond has a high risk of default. And the trouble isn’t isolated to energy bonds. Last week, Bloomberg Business reported that 20% of all U.S. junk bonds are now distressed. That’s the highest level since September 2009. •  Corporate defaults could double in 2016… So far, only 2.6% of junk bonds have defaulted this year. However, that figure will likely jump soon. On Monday, The Wall Street Journal reported that defaults are expected to nearly double to 4.6% next year. If that happens, junk bonds would pass their 30-year average default rate of 3.8%. That also hasn’t happened since 2009. •  Meanwhile, the U.S. stock market is showing big cracks… Last week, we explained how a handful of huge companies are making the U.S. stock market look healthier than it really is. This includes Google (GOOG), Microsoft (MSFT), Amazon (AMZN), Facebook (FB), and Netflix (NFLX). When most investors talk about “the stock market,” they’re talking about the popular S&P 500 index. The S&P 500 is weighted by company size, which means bigger companies affect its performance far more than smaller companies. For example, Google is the second-largest company in the S&P 500. It’s up 43% on the year. Amazon is the sixth-largest company. It’s up 113%. Facebook is the eighth-largest. It’s up 35%. Meanwhile, S&P 500 stocks are trading 18% below their 52-week highs, on average. •  This chart shows what’s really happening in the stock market… It’s one of the most important charts in the world right now… It compares the S&P 500 with a version of the S&P that gives equal weight to every company. In the equally weighted S&P, toymaker Hasbro (HAS) has as much weight as Google, which is 61 times bigger than Hasbro. Only way for Americans to legally pay close to ZERO taxes 70-year-old multimillionaire has revealed greatest – and least known – American tax “loophole.” Click here to get the full details. – •  The U.S. stock market flashed the same red flag in 1999… A handful of big stocks pulled the major indices higher that year, while most U.S. stocks struggled. By 2000, the S&P 500 turned down and went on to lose 48% in 32 months. The NASDAQ crashed 78% in the same time. The U.S. stock market is like a healthy-looking tree that’s actually rotting on the inside. Eventually, when the largest stocks can’t prop it up anymore, the entire tree is going to fall. •  We recommend investing with extreme caution right now… You should hold a significant amount of cash and some physical gold. You may also want to hedge your portfolio by shorting (betting against) stocks likely to crash hard during the next big downturn. This could mean shorting very expensive stocks. It could also mean shorting businesses that will struggle to make money during a prolonged economic slowdown. We recently recorded a video presentation on the topic of investing during difficult times. Doug Casey, founder of Casey Research, gave his advice on how to protect your money and make more money during a major market collapse. Click here to watch – it’s free. Chart of the Day Here’s another clue U.S. stocks are topping out… Professional investors often look at “spreads” to gauge the market’s strength. A spread is the difference between two prices or interest rates. One important spread subtracts the interest rate paid by junk bonds from the interest rate paid by U.S. Treasuries. U.S. Treasuries are bonds issued by the U.S. government, which is widely considered one of the safest borrowers in the world. Junk bonds, on the other hand, are issued by riskier borrowers. Today, the interest rate on Treasuries is 2.1% and the average interest rate on junk bonds is 8.8%. So the “spread” is 6.7%. When the economy is humming along, this spread typically gets smaller. Companies generally make good on their bonds during good economic times, so investors don’t demand a big interest rate premium. However, when the spread starts to get bigger, it’s a sign of trouble ahead for the stock market. For example, this spread started to get bigger in the summer of 2007. Smart investors knew this was a bad sign. They got out of the stock market and saved a ton of money. As you likely remember, the S&P 500 peaked in October 2007, and went on to crash 57%. For the first time in four years, this spread is getting significantly bigger. As you can see, the U.S. stock market and spread moved together while stocks were in a clear-cut bull market through mid-2014 (the spread is inverted on the chart below). Then, they diverged. The spread has more than doubled, while the S&P 500 remains near all-time highs. This is another reason to be very cautious in the stock market today. These two indices tracked each other for most of 2015. However, in recent weeks the S&P 500 has pulled ahead of the equally weighted S&P, which is now down 4% on the year. This is a big red flag. It’s confirmation that a few big companies are holding up the stock market. — Regards, Justin Spittler Delray Beach, Florida December 11, 2015 We want to hear from you. If you have a question or comment, please send it to feedback@caseyresearch.com. We read every email that comes in, and we’ll publish comments, questions, and answers that we think other readers will find useful.last_img read more

Just over four years ago on July 17 2014 six de

Just over four years ago on July 17 2014 six de

first_imgJust over four years ago, on July 17, 2014, six delegates on their way to the International AIDS Conference died in the shoot-down of Malaysia Airlines Flight 17 over eastern Ukraine.The delegates were among the 298 people killed hours after their flight took off from Amsterdam.International investigations concluded that the missile that downed the jet originated with the Russian military, which has denied involvement. This year, Amsterdam is where thousands of experts in public health and global development are gathering for the International AIDS Conference, which begins on Monday.”I’m hopeful that people will still remember them,” Owen Ryan, the outgoing executive director of the International AIDS Society, says of the colleagues he lost in the AIDS prevention research and activism community that day. Ryan told NPR’s Korva Coleman he wants their legacy to help draw attention to AIDS as a continuing crisis, “and know it’s important we keep this fight going.”About 37 million people around the world were living with HIV/AIDS in 2017, according to the World Health Organization. The group says 940,000 people died of HIV-related diseases last year. On the eve of the 22nd International AIDS Conference, Ryan talked with NPR about the current state of the AIDS crisis around the world and why it’s important to keep funding AIDS prevention efforts.Interview HighlightsOn Joep Lange, a former president of the International AIDS Society who died on MH17It’s hard to describe in short ways all the ways that Joep had kind of really transformed the HIV movement. One very large way though was how he made the world wake up to the need for antiretroviral treatment in Africa. He was one of the first researchers, scientists, activists who was forcing donor governments to face the problems that were in Africa — and to get rid of the impediments that were keeping people away from lifesaving treatment.He is in large part to thank for many of the millions of people who are on treatment today. On what can slow down the rate of current AIDS infectionsHonestly, what needs to be done is this sense of complacency that has settled on many of us. There’s really this feeling in many parts of the world that AIDS is over, and that is really far from true.It’s one of the reasons we miss Joep the most right now — he had an unbelievable ability to speak truth to power, regardless of who he’s speaking to. He just knew how to go right to them and say, “What you believe is not true and we need more money for this.”On the development of drugs to stop AIDSFor one of the first times, we’re doing a large-scale clinical trial for vaccines in South Africa. And South Africa’s one of those countries where if we can get it right there, we can get it right in a lot of places around the world. But until we get more people on treatment in the short term, we’re going to keep trying to play catch-up. So we’re really hoping we can do both things at the same time: get people on treatment, and then longer-term prevention options.On particular regions where the AIDS crisis is growingEastern Europe and Central Asia is a big focus of this conference. You’ve seen that over time as economies have improved, donors have walked away. And with them walking away has walked away political will. So in many places, and this also includes Russia, you’ve seen the epidemic come back with force. And you’re seeing in urban centers and rural areas people who are just completely away from treatment and this massive explosion in new infections and I think people just don’t realize it.On preventing future epidemicsWe always have to be aware and it’s the exact moment you take your finger off the pulse of epidemiology that you start to see problems occur. We need to fund the systems that keep us vigilant against the next great disease that’s coming — ’cause we know it’ll happen. We’ve seen this with Ebola, we’ve seen this with SARS in the past. We need to keep things like the CDC and WHO — we need to keep them vibrant and strong and paying attention to all of this. Copyright 2018 NPR. To see more, visit http://www.npr.org/.last_img read more

New statistical tools being developed for mining cancer data

first_imgShareMEDIA CONTACTS:David Ruth713-348-6327david@rice.eduJade Boyd713-348-6778jadeboyd@rice.eduNew statistical tools being developed for mining cancer dataTeam from Rice, BCM, UT Austin tackling big data varietyHOUSTON — (Nov. 13, 2013) — Researchers at Rice University, Baylor College of Medicine (BCM) and the University of Texas at Austin are working together to create new statistical tools that can find clues about cancer that are hidden like needles in enormous haystacks of raw data.“The motivation for this is all of these new high-throughput medical technologies that allow clinicians to produce tons of molecular data about cancer,” said project lead Genevera Allen, a statistician with joint appointments at Rice and BCM. “For example, when a tumor is removed from a cancer patient, researchers can conduct genomic, proteomic and metabolomic scans that measure nearly every possible aspect of the tumor, including the number and location of genetic mutations and which genes are turned off and on. The end result is that for one tumor, you can have measurements on millions of variables.”Genevera AllenThis type of data exists — the National Institutes of Health (NIH) has compiled such profiles for thousands of cancer patients — but scientists don’t yet have a way to use the data to defeat cancer.Allen and BCM collaborator Zhandong Liu teamed up to attack the problem in 2012 thanks to a seed-funding grant from Rice’s Ken Kennedy Institute for Information Technology (K2I). Based on results of that study, Allen, Liu and UT Austin computer scientist Pradeep Ravikumar have won a new $1.3 million federal grant that will allow them to create a new statistical framework for integrated analysis of multiple sets of high-dimensional data measured on the same group of subjects.“There are a couple of things that make this challenging,” said Allen, the principal investigator (PI) on the new grant, which was awarded jointly by the National Science Foundation and the NIH. “First, the data produced by these high-throughput technologies can be very different, so much so that you get into apples-to-oranges problems when you try in make comparisons. Second, for scientists to leverage all of this data and better understand the molecular basis of cancer, these varied ‘omics’ data sets need to be combined into a single multivariate statistical model.”For example, Allen said, some tests, like gene-expression microarrays and methylation arrays, return “continuous data,” numbers with decimal places that represent the amounts of a particular protein or biomarker. Other tests, like RNA-sequencing, return “count data,” integers that indicate how often a biomarker shows up. And for yet other tests, the output is “binary data.” An example of this would be a test for a specific mutation that produces a zero if the mutation does not occur and a one if it does.“Right now, the state of the art for analyzing these millions of biomarkers would be to create one data matrix — think one Excel spreadsheet — where all the numbers are continuous and can be represented with bell-shaped curves,” said Allen, Rice’s Dobelman Family Junior Chair of Statistics and assistant professor of statistics and electrical and computer engineering. “That’s very limiting for two reasons. First, for all noncontinuous variables — like the binary value related to a specific mutation — this isn’t useful. Second, we don’t want to just analyze the mutation status by itself. It’s likely that the mutation affects a bunch of these other variables, like epigenetic markers and which genes are turned on and off. Cancer is complex. It’s the result of many things coming together in a particular way. Why should we analyze each of these variables separately when we’ve got all of this data?”This network model shows a half-million biomarkers related to the type of brain cancer known as glioblastoma. The lines represent “conditionally dependent” connections between biomarkers.Developing a framework where continuous and noncontinuous variables can be analyzed simultaneously won’t be easy. For starters, most of the techniques that statisticians have developed for parallel analysis of three or more variables — a process called multivariate analysis — only work for continuous data.“It is a multivariate problem, and that’s how we’re approaching it,” Allen said. “But a proper multivariate distribution does not exist for this, so we have to create one mathematically.”To do this, Allen, Liu and Ravikumar are creating a mathematical framework that will allow them to find the “conditional dependence relationships” between any two variables.To illustrate how conditional dependence works, Allen suggested considering three variables related to childhood growth — age, IQ and shoe size. In a typical child, all three increase together.“If we looked at a large dataset, we would see a relationship between IQ and shoe size,” she said. “In reality, there’s no direct relationship between shoe size and IQ. They happen to go up at the same time, but in reality, each of them is conditionally dependent upon age.”For cancer genes, where the relationships aren’t as obvious, developing a mathematical technique to decipher conditional dependence could avoid the need to rule out such errors through years of expensive and time-consuming biological experiments.Thanks to the seed-funding grant from K2I’s Collaborative Advances in Biomedical Computing program, Allen and her collaborators have already illustrated how to use these techniques. They’ve produced a network model for a half-million biomarkers related to a type of brain cancer called glioblastoma. The model acts as a sort of road map to guide researchers to the relationships that are most important in the data.“All these lines tell us which genetic biomarkers are conditionally dependent upon one another,” she said in reference to the myriad connections in the model. “These were all determined mathematically, but our collaborators will test some of these relationships experimentally and confirm that the connections exist.”Allen said the team’s technique will also be useful for big data challenges that exist in fields ranging from retail marketing to national security.“This is a very general mathematical framework,” she said. “That’s why I do math. It works for everything.”Allen is also an assistant professor of pediatric neurology at BCM and a member of the Jan and Dan Duncan Neurological Research Institute at Texas Children’s Hospital.K2I’s Collaborative Advances in Biomedical Computing program, which is made possible by the John and Ann Doerr Fund for Computational Biomedicine, supports research collaborations between Rice and other institutions in the Texas Medical Center that focus on computing, computational science and engineering as key enablers for biomedical research.###High-resolution IMAGES are available for download at:http://news.rice.edu/files/2013/11/1111-ALLEN-glio-network-lg.jpgCAPTION: This network model shows a half-million biomarkers related to the type of brain cancer known as glioblastoma. The lines represent “conditionally dependent” connections between biomarkers.CREDIT: G. Allen/Rice Universityhttp://news.rice.edu/files/2013/11/1111-ALLEN-bcm-lg.jpgCAPTION: Genevera AllenCREDIT: Baylor College of MedicineA copy of the NSF grant abstract is available at:http://www.nsf.gov/awardsearch/showAward?AWD_ID=1264058Located on a 300-acre forested campus in Houston, Rice University is consistently ranked among the nation’s top 20 universities by U.S. News & World Report. Rice has highly respected schools of Architecture, Business, Continuing Studies, Engineering, Humanities, Music, Natural Sciences and Social Sciences and is home to the Baker Institute for Public Policy. With 3,708 undergraduates and 2,374 graduate students, Rice’s undergraduate student-to-faculty ratio is 6-to-1. Its residential college system builds close-knit communities and lifelong friendships, just one reason why Rice has been ranked No. 1 for best quality of life multiple times by the Princeton Review and No. 2 for “best value” among private universities by Kiplinger’s Personal Finance. To read “What they’re saying about Rice,” go to http://tinyurl.com/AboutRiceU. AddThislast_img read more

CDC selects UMass Amherst biostatistician model that helps predict influenza outbreaks

first_imgReviewed by James Ives, M.Psych. (Editor)Dec 13 2018When the Centers for Disease Control and Prevention was looking for a preferred flu prediction model for use in its flu-forecasting challenge this season, an influenza-tracking model developed by a team led by biostatistician Nicholas Reich at the University of Massachusetts Amherst rose to the top and will be one of its principal prediction tools, Reich says.Reich, whose UMass-led collaborative is made up of six teams, says, “We competed in the CDC challenge last year and out of 30 models the CDC received to help predict the flu season, ours was the second best. This year we’re re-tooling some of our models and the CDC has chosen our model to try to optimally predict seasonal influenza outbreaks.””It’s a nice accomplishment,” he adds. “Apparently our collaborative approach that fuses multiple different models together impressed them as being better and more reliable than all of the other approaches they have seen over the past few years. We hope we can contribute quite a bit to this year’s efforts.”In an international group dubbed the “FluSight Network,” Reich at UMass Amherst’s School of Public Health and Health Sciences, with colleagues at Carnegie Mellon University, the CDC, Columbia University, Los Alamos National Laboratory, Mount Holyoke College, and a consulting group from South Africa called Protea Analytics, issue a new flu season forecast starting in late fall every Monday for public health researchers and practitioners. It compares the flu trajectory this year to past years.”This entire effort is public, so anyone can go to the website and see the forecasts and even get at the raw data underlying them,” Reich points out. They work year-round to develop a way for all their models to work together to make a single best forecast for influenza, a method they call a “multi-model ensemble approach.”In addition to his work on the influenza-tracking team, Reich writes an occasional blog on “what we are, and are not, ready for” when it comes to flu season. Last September, he was one of just four influenza forecasters in the nation invited to participate in the CDC’s first flu pandemic simulation workshop, which included mock press conferences by officials including the CDC director. The exercise allowed the agency to run through several scenarios about how a flu pandemic might be forecast from early data, how it could be tracked and how integrating advanced analytic processes into decision-making might assist with those projections.Among other things, Reich says, the workshop was a recognition by the CDC that a network of forecasters that exists in academia and industry today but not in the public sector, might help decision-makers to use the data as one of their inputs when making choices.Related StoriesNaturally occurring human antibody reveals hidden weakness in influenza virusStudy provides insight on how two proteins help influenza A virus to fight its way to cellsStudy uncovers potential new strategy to treat influenza AHe says, “We work very closely with our collaborators at the CDC. Without their vision and careful design of this challenge five years ago, we wouldn’t be where we are today. This collaboration has added a lot of value to the laudable efforts that they have made over these years to integrate data and modeling into real-time public health decision-making,” he adds. “The value of the ensemble approach is becoming clear to all observers and that workshop helped to demonstrate it.”Now in its second year of participating in the CDC challenge, the FluSight Network gets a little better each year at refining flu projection models, Reich says. These help the experts prepare public flu messages, assess disease severity and regional incidence, project peak impact and other factors important to public health officials.Not only health professionals, but health writers and reporters watch the CDC’s weekly updates each week, the biostatistician says. “The first question of the season is when is it going to start. That is, when will the number of cases go above the baseline of flu activity by region, which is the first checkpoint of every season. Hospitals, clinics, family physicians all keep their eye on this information to help them prepare.””So far this flu season, a few regions of the U.S., including the Northeast, have been seeing slightly higher levels of flu-like activity than normal, but the most recent data suggest that the levels are still below what the CDC defines as a ‘baseline’ level of activity,” he points out.”That said, our models are saying that we should perhaps expect a bit of an early onset to the season in the Northeast and a few other regions,” Reich adds. “The ensemble model isn’t picking up a clear signal yet about how different from a normal year the peak incidence might be in terms of timing or severity. In coming weeks, we think the models may show a bit more separation from the historical average. Right now, though, it’s a little like looking at a 30-day weather forecast and trying to use that to decide whether it’s going to snow on any particular day. Our models just can’t reliably see that far into the future at the moment.”For their prediction efforts, each team submits eight seasons of influenza forecasts from the past to the UMass-led model. “This approach allows us to do better than a simple average of all models,” Reich says, “because we can employ them proportionally based on their success. Each model has different strengths based on the data or the methodological approach they use. Some models this season are incorporating data from a variety of internet data, including signals from Twitter, Google Search activity and Wikipedia.” Source:https://www.umass.edu/newsoffice/article/umass-amherst-biostatistician-and-nationallast_img read more

Children are attuned to social bias at a surprisingly young age finds

first_imgReviewed by James Ives, M.Psych. (Editor)Jan 24 2019In a Developmental Science study of preschool-aged children, implicit and explicit evaluations of Black boys were less positive than evaluations of Black girls, White boys, or White girls.This “gendered racial bias” was exhibited by both White and non-White children and was not correlated with their exposure to diversity. It also mirrors social bias observed in adults.The study, which reveals the earliest evidence of bias at the intersection of race and gender, underscores the importance of addressing bias in the first years of life.”Our results suggest that children are attuned to nuanced patterns of social bias at a surprisingly young age,” said lead author Danielle Perszyk, of Northwestern University. “This means that efforts to counter such bias must begin very early in children’s development.”Source: https://newsroom.wiley.com/press-release/developmental-science/study-reveals-bias-children-even-they-reach-kindergartenlast_img read more

Huge Malaria vaccine trial in Malawi

first_imgPeter Sands, Executive Director of the Global Fund in his statement added, “To step up the fight against malaria, we need every available tool. If this pilot shows that RTS,S is a cost-effective tool against malaria, it will help us save more children’s lives.” Dr Seth Berkley, CEO of Gavi in his statement said, “Malaria is still one of the biggest killers of children worldwide, taking the lives of over 200,000 children every year. These pilots will be crucial to determine the part this vaccine could play in reducing the burden this disease continues to place on the world’s poorest countries.” The vaccine known as RTS,S or Mosquirix, would be administered to children up to 2 years of age. After Malawi, the vaccine would be introduced in its pilot trial phase in Ghana and Kenya in the coming weeks. In these African countries malaria remains a menace and kills with an alarming frequency of one child every two minutes. In Africa, over 250,000 children die due to malaria annually. The risks of dying due to malaria and its complications are highest among children under the age of five years. Across the world, malaria kills 435,000 people annually of which most are children says WHO. The team leading the pilot trial would roll out the programme and help to generate information and experience with the RTS,S malaria vaccine so that WHO can devise its policy recommendations regarding the vaccine. The utility and efficacy of the vaccine in reducing childhood deaths, safety of the vaccines, if the parents were willing to bring their children for the routine four doses of the vaccine and its general acceptance would all be studied.WHO officials add, that this new malaria vaccine would be part of the malaria control programme. WHO recommends other major measures for malaria control including insecticide-treated bed nets, use of insecticides indoors and routine testing for malaria in case of fever and its early treatment.This pilot programme is a collaboration between the WHO and ministries of health in Ghana, Kenya and Malawi along with PATH, a non-profit organization and makers of the vaccine GSK. GSK is donating up to 10 million vaccine doses for this pilot project. This pilot project is receiving financial support from Gavi, the Vaccine Alliance; the Global Fund to Fight AIDS, Tuberculosis and Malaria; and Unitaid. Contributions in kind are being provided by WHO, PATH and GSK. Steve Davis, President and CEO of PATH said in a statement, “We salute WHO and Malawi for their leadership in realizing this historic milestone and we look forward to the start of vaccination in Ghana, and then Kenya later this year. A vaccine for malaria is among many innovations needed to bring an end to this disease, and we proudly stand with all countries and our many partners in progressing towards a malaria-free world.” Dr Matshidiso Moeti, WHO Regional Director for Africa, in a statement said, “Malaria is a constant threat in the African communities where this vaccine will be given. The poorest children suffer the most and are at highest risk of death. We know the power of vaccines to prevent killer diseases and reach children, including those who may not have immediate access to the doctors, nurses and health facilities they need to save them when severe illness comes. This is a day to celebrate as we begin to learn more about what this tool can do to change the trajectory of malaria through childhood vaccination.” Malaria vaccine trial in Malawi. Image Credit: WHO This malaria vaccine took three decades to make say researchers. Until now it remains the only vaccine against malaria. Phase 3 clinical trials with the vaccine have been conducted in Africa between 2009 and 2014. These clinical trials with this vaccine show that this vaccine could prevent 40 percent of malaria cases and 30 percent of fatal severe malaria cases. Dr David Schellenberg, one of the researchers who helped develop the vaccine said in a statement, “There were seven countries participating in a large trial where over 15,000 children participated. [The trial] showed pretty clearly that this vaccine is safe and it is efficacious in terms of its ability to prevent clinical malaria episodes and also severe malaria episodes.”#Malawi 🇲🇼: A baby girl named Gloria was first in line for a #malariavaccine at the Muotcha HIV Testing & Counseling Centre in the town of Balaka. pic.twitter.com/EYGh46XcB7— WHO African Region (@WHOAFRO) April 24, 2019 Similarly Lelio Marmora, Executive Director of Unitaid added, “The malaria vaccine is an exciting innovation that complements the global health community’s efforts to end the malaria epidemic. It is also a shining example of the kind of inter-agency coordination that we need. We look forward to learning how the vaccine can be integrated for greatest impact into our work.” According to WHO Director-General Dr Tedros Adhanom Ghebreyesus in a statement, “We have seen tremendous gains from bed nets and other measures to control malaria in the last 15 years, but progress has stalled and even reversed in some areas. We need new solutions to get the malaria response back on track, and this vaccine gives us a promising tool to get there. The malaria vaccine has the potential to save tens of thousands of children’s lives.” Further Reading What is Malaria? Malaria Causes Malaria Mechanism Malaria Diagnosis Malaria Prevention Malaria Treatment Malaria Epidemiology Malaria Society And Culture Malaria Symptoms The pilot programme is slated to reach around 360,000 children annually in the three target nations. The areas covered would be regions where malaria transmission is high and the vaccine would be of greater help say officials. There would be four doses of the vaccine for each child – 3 doses to be administered between 5 and 9 months of age and the fourth dose to be administered at around the age of 2 years.A PATH white paper on this project says, “Looking ahead The pilot implementation was designed as a six-year program, including preparation, and the evaluations are now expected to be completed by 2023. Its goal is to enable an updated WHO policy recommendation on the possible broader use of RTS,S in African children by generating additional evidence on feasibility, impact, and safety—all in the context of routine use.” By Dr. Ananya Mandal, MDApr 24 2019This week the African nation of Malawi became one of the first of the planned three to launch a pilot trial for a novel vaccine against malaria. The news and the efforts were lauded by the World Health Organization (WHO). Dr Thomas Breuer, Chief Medical Officer of GSK Vaccines in a statement said, “Delivering the world’s first malaria vaccine will help reduce the burden of one of the most pressing health challenges globally. This novel tool is the result of GSK employees collaborating with their partners, applying the latest in vaccine science to contribute to the fight against malaria. We look forward to seeing the results of the pilot, and in parallel, are working with WHO and PATH to secure the vaccine’s sustained global health impact in the future.”last_img read more

Circulating tumor DNA can help detect treatment options for ovarian cancer subtype

first_imgReviewed by James Ives, M.Psych. (Editor)May 6 2019According to a new research, circulating tumor DNA can be used detect treatment options for ovarian cancer patients who don’t benefit from chemotherapy.High-grade serous ovarian cancer (HGSOC) is the most common and aggressive subtype of ovarian cancer. The HGSOC tumors consist of several heterogeneous cell populations with a large number of mutations. This genetic variability makes it difficult to find drugs that would kill all the cancer cells, and to which the cells would not become resistant during treatment.Over half of the patients diagnosed with high-grade serous ovarian cancer die within five years of diagnosis, that is, annually more than 150000 women globally. To improve the efficacy of HGSOC treatment, a research group from University of Helsinki, together with researchers from University of Turku and Turku University Hospital, have now studied the use of circulating tumor DNA in finding precision medicine-based treatments for the disease.Circulating tumor DNA refers to tumor-derived cell-free DNA in the bloodstream. Circulating tumor DNA detection is a minimally invasive technique that offers dynamic “molecular snapshots” of genomic alterations in cancer.”Analyzing circulating tumor DNA enables us to detect genomic alterations also in late stage cancers in which taking biopsies from the tumor is difficult or even impossible. In the current research, we demonstrated that circulating tumor DNA can be used to monitor the patient responses to treatment, and find drug combinations to target the Achilles’ heels of the tumor’s genomic profile,” says Professor Sampsa Hautaniemi, director of the Systems Oncology Research Program in the Faculty of Medicine at University of Helsinki.Related StoriesSpecial blood test may predict relapse risk for breast cancer patientsBacteria in the birth canal linked to lower risk of ovarian cancerUsing machine learning algorithm to accurately diagnose breast cancerThe results were published in JCO Precision Oncology.Hautaniemi’s research group has implemented a clinical circulating tumor DNA workflow to detect clinically actionable alterations in more than 500 cancer-related genes.In the present study, the researchers analyzed 78 circulating tumor DNA samples from 12 ovarian cancer patients before, during and after the treatment using bioinformatics analysis, and in-house Translational Oncology Knowledgebase to detect clinically actionable genomic alterations.DNA alterations associated with clinically available drugs were detected in 58% of the patients. The treatment of one patient has already been tailored successfully based on the results. For the other patients the results may be useful if their cancer relapses.The results demonstrate a proof-of-concept for using circulating tumor DNA to guide clinical decisions. Furthermore, the results show that longitudinal circulating tumor DNA samples can be used to identify poor-responding patients after first cycles of chemotherapy.In addition, the researchers provide the first comprehensive, open-source circulating tumor DNA workflow for detecting clinically actionable alterations in solid cancers.”The prognosis of ovarian cancer patients is still poor. However, the future looks brighter as research has discovered targeted therapies for the genomic alterations also in ovarian cancer tumors. We are currently in the forefront of the precision medicine for ovarian cancer. Our goal is to find out how ovarian cancer becomes resistant to current treatments, and use this knowledge in finding more effective precision treatments,” Hautaniemi says. Sources:The University of Helsinki.Journal reference:Jaana Oikkonen et al. (2019) Prospective longitudinal ctDNA workflow reveals clinically actionable alterations in ovarian cancer. JCO Precision Oncology. doi.org/10.1200/PO.18.00343.last_img read more

Research on cannabis use in women limited finds new study

first_imgImage Credit: OpenRangeStock / Shutterstock In 2016, over 190 million people in the world used cannabis, making it the third most commonly used drug in the world. Cannabis use is linked to certain risks, most notably that of psychosis.Cannabis psychosis has a tremendous negative impact on both cannabis users and their families. The relationship between cannabis and psychosis has been a bone of contention for a long time among addiction researchers. An accurate understanding of this would help greatly to direct limited health resources towards those at highest risk.While this association has been known for more than a hundred years, increasing cannabis use in the Western world brought it to the attention of researchers. Andreasson et al. performed a foundational study (in male users) which set the direction for research in this area for decades. They concluded that cannabis independently increased the risk of developing schizophrenia, to 6% of heavy users.Researchers have not yet been able to determine at what point cannabis-induced psychosis may be diagnosed. Both acute and long-term psychotic reactions occur, which means the statistics vary with place, assessor, and type of evaluation.Scientists currently favor one of three explanations for the link between cannabis use and schizophrenia. One, cannabis use triggers schizophrenia in some individuals. This is difficult to prove, because cannabis metabolites continue to be excreted in urine for weeks following a single use, which enormously increases the chances of a false diagnosis of cannabis psychosis.Two, schizophrenics use cannabis to treat their early symptoms. This, however, belies the most common reasons given by the users themselves to explain why they use the drug, namely, pleasure and recreation.Certain cannabidiols are useful in treating schizophrenia, adding plausibility to the theory. Against this we must set the fact that in recent times the concentration of the potent and pro-psychosis compound Δ9-tetrahydrocannabinol (THC) has risen, relative to the less potent cannabidiols (CBD) in cannabis.Related StoriesAMSBIO offers new, best-in-class CAR-T cell range for research and immunotherapyAXT enhances cellular research product portfolio with solutions from StemBioSysSchwann cells capable of generating protective myelin over nerves finds researchFinally, there are factors which predispose to both schizophrenia and to cannabis use.Ian Hamilton, the author of the current study, observes that cannabis is being legalized in many countries worldwide, for medical and recreational use. Yet, at the same time, we are possibly missing important information on the topic because of inadequate research.Most research has concentrated on teasing out genetic and biologic risk factors for cannabis psychosis. This means that we have largely neglected the impact of social and cultural factors which may be just as important.  In the current study, which carried on past work from the same institution, two issues came to the fore.The first was an obvious lack of female representation in cannabis research. Women cannabis users are simply not present in the vast majority of cannabis studies. Hamilton cites a possible link to the lack of women scientists in the field of addiction research.The second issue relates to the focus of addiction studies in the developed world. Most researchers in this field have focused on America, Europe and Australia, leaving out vast and populous areas like Africa, Asia and the Middle East.Studying cannabis use and effects in other cultures and regions could help us understand the risk factors for cannabis psychosis much better. For instance, is the low incidence of psychosis in some regions of Asia linked to the smaller population of cannabis users there?Again, is tobacco synergistic with cannabis in increasing the psychosis risk? Knowing this could enable us to focus on helping cannabis users quit tobacco to reduce this risk.The study concludes that we need much more research to elucidate the risk factors for cannabis psychosis. This should include many more women cannabis users as well as other geographical areas of the world.Hamilton says, “We need to accept that cannabis psychosis is about more than genetics or biology but is effected by social factors such as where and how young people grow up and the problems they experience as they develop.” The increasing legal access to cannabis in America “presents a large naturalistic experiment”, he says, which will provide data in a few years on how cannabis affects health and psychosis trends in the population. By Dr. Liji Thomas, MDJun 5 2019A new study from the University of York shows that research into the association of psychosis with cannabis focuses almost completely on men users, significantly limiting our knowledge of the drug’s effects on human health.center_img Source: Hamilton, I. and Monaghan, M. (2019). Cannabis and Psychosis: Are We any Closer to Understanding the Relationship? Current Psychiatry Reports. https://link.springer.com/article/10.1007%2Fs11920-019-1044-xlast_img read more

PM Modi slams Uturn CM Chandrababu NaiduPM Modi slams Uturn CM Chandrababu

first_img COMMENT SHARE SHARE SHARE EMAIL Prime Minister Narendra Modi (file photo)   –  PTI AP CM calls for “black day” on Friday against Centre Naidu deceiving AP: KTR “I understand he has exhausted all the negative words and epithets in the rich Telugu language in heaping abuse on me. But what is my crime?,” the Prime Minister asked. February 10, 2019center_img political campaigns COMMENTS state politics Prime Minister Narendra Modi reiterated here on Sunday that his Government would always strive for the welfare of the people of Andhra Pradesh and “it is the U-turn Chief Minister of the State, Sriman Chandrababu Naidu, who is responsible for the difficulties faced by the people of Andhra Pradesh”.Protests were organised by different the TDP, Congress and the Communists at Vijayawada, Guntur and other places in the State, urging the PM to “go back” as “he had betrayed the interests of the state by not fulfilling his promise on granting special category status to the State” and “not releasing enough funds to the State in the aftermath of bifurcation”. The Prime Minister was speaking at a public meeting organised by the BJP after dedicating two major projects in the State to the nation – the strategic crude oil storage facility at Visakhapatnam with a capacity of 1.33 million tonnes built at a cost of Rs 1,125 crores and S 1 Vashista gas field development project in the Krishna-Godavari basin taken up by the ONGC at a cost of Rs 5,700 crores. He also laid the foundation stone for the coastal installation facility being constructed at Krishnapatnam port by the BPCL at a cost of Rs 2,280 crores. In his hour-long speech, the PM devoted 15 minutes to talking about the three oil and gas projects and how they would help the State and the country and the remaining 45 minutes to castigating the Chief Minister Chandrababu Naidu, his son and the State IT Minister Nara Lokesh and the TDP.’U-turn’ Modi said the NDA Government had sanctioned a special assistance package in lieu of the promised special category status (SCS) and was taking all steps to implement it, “but after accepting it whole-heartedly and passing a resolution in the State Assembly thanking the Centre, the Chief Minister has now changed his stand and taken a U-turn. He is abusing the BJP and me personally, day in and day out. I understand he has exhausted all the negative words and epithets in the rich Telugu language in heaping abuse on me. But what is my crime?,” he asked.The Prime Minister said the NDA Government had sanctioned projects worth more than Rs 3 lakh crores to the State during the past four-and-a-half years and several of them had already been grounded and several were in various stages of execution. “The AP Reorganisation Act, 2014, has given a period of ten years and we are sincerely implementing all the provisions of the Act in letter and spirit. Suddenly, the CM has taken a U-turn after four years for his political gains and he is busy spreading misinformation.”‘Son’ rise?The Prime Minister accused the CM of betraying “the great legacy of NTR who founded the Telugu Desam Party and fought against the corrupt Congress. His son-in-law who back-stabbed him during his lifetime has now joined hands with the Congress. NTR’s soul must be writhing in agony.”Taking a swipe at the CM, the PM said, “Sri Chandrababu Naidu often speaks of sunrise Andhra Pradesh. Is it sunrise or son rise, he should clarify. He is devoting most of his time to promote his son, Lokesh. The people of AP have seen how father-son duo is ruining the interests of the State.”Thanking the TDP workers for organising protests urging him to “go back”, he remarked, “I shall certainly go back to New Delhi after emerging victorious in the coming elections. I accept the blessings of my TDP friends. But what will happen to them and their leader as they are sure to be defeated.”He alleged that “the fear of impending defeat has gripped the Andhra CM and that explains his recent action and his unholy alliance with the Congress.”The Prime Minister said the people of Andhra would see through the designs of the CM and bless his party, the BJP, in the coming elections. The PM’s speech was translated into Telugu by GVL Narasimha Rao, a BJP member of the Rajya Sabha. Earlier, K. Lakshminarayana, the State BJP unit leader, also spoke. RELATED Published onlast_img read more

Accept resignations of MLAs at once Bihar Speaker urges Ktaka counterpart

first_imgAccept resignations of MLAs at once: Bihar Speaker urges K’taka counterpartBihar Assembly Speaker Vijay Kumar Chaudhary on Friday voiced disapproval over the “delay” on part of his Karnataka counterpart KR Ramesh Kumar in taking a decision on the resignations of MLAs of the ruling Congress-JD(S) coalition in the southern state.advertisement Next Press Trust of India PatnaJuly 13, 2019UPDATED: July 13, 2019 00:14 IST Karnataka Assembly Speaker KR Ramesh Kumar (ANI)Bihar Assembly Speaker Vijay Kumar Chaudhary on Friday voiced disapproval over the “delay” on part of his Karnataka counterpart K R Ramesh Kumar in taking a decision on the resignations of MLAs of the ruling Congress-JD(S) coalition in the southern state.”The matter has been unnecessarily allowed to snowball the Speaker (of Karnataka) indeed had no option when the members had met him personally and tendered their resignations,” Chaudhary said in the release issued by the Vidhan Sabha secretariat here.”Delay on part of the Speaker is surprising. It appears he has been thinking in terms of getting the members disqualified on ground of their defying the party whip. However, their resignations have preceded issuing of any whip by their parties and such a course of action by the Speaker would not have been in accordance with norms,” Chaudhary said.He said defiance of whip would have made no difference as action taken under the 10th Schedule of Constitution (anti-defection law) also has the same effect, that of a member being disqualified.”The delay has led to a situation wherein the matter has reached the Supreme Court and the action of the assembly Speaker has been subjected to judicial scrutiny… instances like these lower the dignity of the legislature and hamper its credibility. It would be better for the Speaker to accept the resignations without any delay. This would enhance his stature and protect the dignity of the legislature,” the Bihar Assembly Speaker added.The Supreme Court Friday restrained the Karnataka Speaker from taking any decision till Tuesday on the resignation and disqualification of 10 rebel MLAs.The 10 rebel MLAs moved the apex court alleging that the Speaker was not accepting their resignations.They are: Pratap Gouda Patil, Ramesh Jarkiholi, Byrati Basavaraj, B C Patil, S T Somashekhar, Arbail Shivaram Hebbar, Mahesh Kumathalli, K Gopalaiah, A H Vishwanath and Narayana Gowda.ALSO READ | Kumaraswamy wants floor test, SC asks Speaker to not act on resignations | All that happenedALSO WATCH | Kumaraswamy trust vote offer a googly or full toss?For the latest World Cup news, live scores and fixtures for World Cup 2019, log on to indiatoday.in/sports. Like us on Facebook or follow us on Twitter for World Cup news, scores and updates.Get real-time alerts and all the news on your phone with the all-new India Today app. Download from Post your comment Do You Like This Story? Awesome! Now share the story Too bad. Tell us what you didn’t like in the comments Posted byAnupriya Thakur Tags :Follow Karnataka crisislast_img read more

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Lets prevent this from happening to others. read more